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Unresolved questions regarding the promise of the TPEx regimen.

作者信息

Kosaka Makoto, Honma Yoshitaka, Ishiki Hiroto

机构信息

Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Department of Head and Neck, Esophageal Medical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.

出版信息

Lancet Oncol. 2021 Jun;22(6):e227. doi: 10.1016/S1470-2045(21)00246-1.

DOI:10.1016/S1470-2045(21)00246-1
PMID:34087137
Abstract
摘要

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Unresolved questions regarding the promise of the TPEx regimen.关于TPEx方案前景的未解决问题。
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Cetuximab, docetaxel, and cisplatin versus platinum, fluorouracil, and cetuximab as first-line treatment in patients with recurrent or metastatic head and neck squamous-cell carcinoma (GORTEC 2014-01 TPExtreme): a multicentre, open-label, randomised, phase 2 trial.西妥昔单抗、多西他赛和顺铂与顺铂、氟尿嘧啶和西妥昔单抗联合用于复发性或转移性头颈部鳞状细胞癌患者的一线治疗(GORTEC 2014-01 TPExtreme):一项多中心、开放标签、随机、2 期临床试验。
Lancet Oncol. 2021 Apr;22(4):463-475. doi: 10.1016/S1470-2045(20)30755-5. Epub 2021 Mar 5.
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Unresolved questions regarding the promise of the TPEx regimen - Authors' reply.关于TPEx方案前景的未解决问题——作者回复
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Oral Oncol. 2017 May;68:114-118. doi: 10.1016/j.oraloncology.2017.03.009. Epub 2017 Mar 24.
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A Multicenter Phase II Trial of Docetaxel, Cisplatin, and Cetuximab (TPEx) Followed by Cetuximab and Concurrent Radiotherapy for Patients With Local Advanced Squamous Cell Carcinoma of the Head and Neck (CSPOR HN01: ECRIPS Study).多西他赛、顺铂和西妥昔单抗序贯西妥昔单抗并同步放疗治疗局部晚期头颈部鳞状细胞癌的多中心II期试验(TPEx)(CSPOR HN01:ECRIPS研究)
Front Oncol. 2019 Jan 22;9:6. doi: 10.3389/fonc.2019.00006. eCollection 2019.
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Modified TPEx as First-line Treatment for Recurrent and/or Metastatic Head and Neck Cancer.采用改良 TPEx 作为复发和/或转移性头颈部癌症的一线治疗方法。
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Cetuximab, fluorouracil and cisplatin with or without docetaxel for patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (CeFCiD): an open-label phase II randomised trial (AIO/IAG-KHT trial 1108).西妥昔单抗联合氟尿嘧啶和顺铂或多西他赛治疗复发性和/或转移性头颈部鳞状细胞癌患者(CeFCiD):一项开放标签、二期随机试验(AIO/IAG-KHT 试验 1108)。
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