MN1 诱导白血病发生的 BAFfling 故事。
The BAFfling story of MN1-induced leukemogenesis.
机构信息
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Molecular Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
出版信息
Mol Cell. 2021 Jun 3;81(11):2268-2269. doi: 10.1016/j.molcel.2021.05.001.
Abstract
Riedel et al. (2021) show that expression of MN1 is capable of blocking myeloid differentiation and initiating leukemia through mechanisms that require Brg1-containing chromatin remodeling complexes. Intriguingly, this process depends on an unstructured polyglutamine repeat region within MN1.
摘要
里德尔等人（2021 年）表明，MN1 的表达能够通过需要包含 Brg1 的染色质重塑复合物的机制来阻断髓样分化并引发白血病。有趣的是，这个过程依赖于 MN1 内的一个无结构的多聚谷氨酰胺重复区域。
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