Department of Pharmacy, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Regul Toxicol Pharmacol. 2021 Aug;124:104970. doi: 10.1016/j.yrtph.2021.104970. Epub 2021 Jun 2.
Statin is biologically plausible in cataract development, but inconclusive associations between statin and cataract are presented in human studies. Given most early onset cataract (EOC) occurs in regions with high cholesterol composition, we therefore aimed to assess the association between statin and EOC.
A population based case-control study was performed using the Taiwan National Health Insurance Research Database (NHIRD). The case involved patients aged 20-55 years with EOC. Controls were 1:1 matched by age, gender, year of index date, and propensity score estimated from comorbidities and comedications. Statin exposure, including intensity, properties and cumulative exposure one year before the index date were tracked. The odds ratios (ORs) of EOC associated with statin were estimated by conditional logistic regression.
A total of 4213 cases and 4213 controls were included. Statins were associated with EOC (OR = 3.257, 95% CI 2.519-4.211). The ORs of cataract was positively associated with cumulative exposure. Subgroup analysis indicated that the ORs of cataract were significant both in lipophilic (OR = 3.485, 95% CI 2.606-4.659) and hydrophilic (OR = 3.241, 95% CI 1.975-5.321) statin users.
Statins were associated with an increased risk of cataract in young populations.
他汀类药物在白内障发展中具有生物学合理性，但人类研究中他汀类药物与白内障之间的关联尚无定论。鉴于大多数早发性白内障（EOC）发生在胆固醇含量高的地区，因此我们旨在评估他汀类药物与 EOC 之间的关联。
使用台湾全民健康保险研究数据库（NHIRD）进行了一项基于人群的病例对照研究。病例组包括年龄在 20-55 岁之间患有 EOC 的患者。对照组按年龄、性别、索引日期年份和从合并症和合并用药中估计的倾向得分进行 1:1 匹配。在索引日期前一年跟踪他汀类药物的暴露情况，包括强度、特性和累积暴露量。使用条件逻辑回归估计与他汀类药物相关的 EOC 的比值比（OR）。
共纳入 4213 例病例和 4213 例对照。他汀类药物与 EOC 相关（OR=3.257，95%CI 2.519-4.211）。白内障的 OR 与累积暴露量呈正相关。亚组分析表明，亲脂性（OR=3.485，95%CI 2.606-4.659）和亲水性（OR=3.241，95%CI 1.975-5.321）他汀类药物使用者的白内障 OR 均具有统计学意义。
他汀类药物与年轻人群白内障风险增加相关。
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