用于抗癌药物（5-氟尿嘧啶）控释的皮下聚合物基质系统聚（甲基丙烯酸羟乙酯-丁二醇二酸酯）。I. 合成与结构。

Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). I. Synthesis and structure.

作者信息

Denizli A, Kiremitçi M, Pişkin E

机构信息

Hacettepe University, Chemical Engineering Department, Ankara, Turkey.

出版信息

Biomaterials. 1988 May;9(3):257-62. doi: 10.1016/0142-9612(88)90094-4.

DOI:10.1016/0142-9612(88)90094-4

PMID:3408798

Abstract

The present study was an attempt to design a new polymer-drug composite system for local chemotherapy. Poly(hydroxyethylmethacrylate-bisglycolacrylate) carriers containing an anticancer drug, 5-fluorouracil, were prepared by low temperature radiation polymerization technique. By changing the relative amounts and the types of ingredients, drug loading and radiation dosage, polymer-drug composites with different structural properties were obtained. This paper presents the preparation procedure and analyses some of the structural properties of these novel composites.

摘要

本研究旨在设计一种用于局部化疗的新型聚合物-药物复合体系。通过低温辐射聚合技术制备了含有抗癌药物5-氟尿嘧啶的聚（甲基丙烯酸羟乙酯-双丙烯酸二醇酯）载体。通过改变成分的相对含量和类型、药物负载量和辐射剂量，获得了具有不同结构性质的聚合物-药物复合材料。本文介绍了这些新型复合材料的制备过程，并分析了其一些结构性质。