Fattal-German M, German A, Bizzini B
Université de Paris-Sud, Laboratoire de Microbiologie, Faculté de Pharmacie, Châtenay-Malabry, France.
Biomed Pharmacother. 1988;42(1):73-8.
Influenza vaccination is highly desirable in view of the epidemic character of this infection and of the severity that it can assume in high-risk and in elderly persons. Its effectiveness varies from 40-90%. Moreover, strains can undergo an antigenic drift in the course of an epidemic. Consequently, reinforcement of the immunogenicity of vaccines is required for achieving a more complete immunization coverage. Combination of an immunomodulator, the C. granulosum-derived P40 fraction, with influenza vaccine resulted in significant potentiation of vaccine immunogenicity. In addition to its adjuvant action, the P40 is also likely to exercise a protective effect by stimulating the non-specific immune defenses of the organism.
鉴于这种感染的流行性以及它在高危人群和老年人中可能呈现的严重性，流感疫苗接种非常必要。其有效性在40%至90%之间。此外，毒株在流行过程中可能会发生抗原漂移。因此，需要增强疫苗的免疫原性以实现更全面的免疫覆盖。免疫调节剂——颗粒丙酸杆菌衍生的P40组分与流感疫苗联合使用，可显著增强疫苗的免疫原性。除了其佐剂作用外，P40还可能通过刺激机体的非特异性免疫防御发挥保护作用。
