Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Pediatr Blood Cancer. 2021 Sep;68(9):e29135. doi: 10.1002/pbc.29135. Epub 2021 Jun 5.
Standardized programming for individuals with sickle cell disease (SCD) transitioning from pediatric to adult-centered care does not currently exist, resulting in high rates of mortality and morbidity. This scoping review examines and evaluates the current literature on SCD transition programs and interventions. Eligible studies described an existing program for individuals with SCD aged 12-29 years preparing to transition. The Evidence Project risk-of-bias tool was used to assess article quality. We identified 30 eligible articles, of which, only two were randomized controlled trials. Many studies have incomplete reports of feasibility information, such as completion rates, patient characteristics, and attrition; all studies were limited to a single institution; and most studies were rated high for risk of bias. Progress has been made in designing and gathering initial evaluation data for SCD transition programs; however, there is a need for higher quality studies, consistent assessment, and better dissemination of programs.
目前，针对镰状细胞病（SCD）患者从儿科向成人为中心的护理过渡的标准化编程尚不存在，这导致了高死亡率和发病率。本范围综述检查和评估了关于 SCD 过渡计划和干预的现有文献。合格的研究描述了一项针对 12-29 岁准备过渡的 SCD 患者的现有计划。使用证据项目偏倚风险工具评估文章质量。我们确定了 30 篇合格的文章，其中只有两项是随机对照试验。许多研究对可行性信息的报告不完整，例如完成率、患者特征和流失率；所有研究都仅限于单一机构；并且大多数研究的偏倚风险被评为高。在设计和收集 SCD 过渡计划的初始评估数据方面已经取得了进展；然而，需要更高质量的研究、一致的评估和更好的计划传播。
