Maxwell D J, Crawford D C, Curry P V, Tynan M J, Allan L D
Department of Perinatal Cardiology, Guy's Hospital, London.
BMJ. 1988 Jul 9;297(6641):107-10. doi: 10.1136/bmj.297.6641.107.
During 1980-7, 23 pregnancies of 22-38 weeks' duration were investigated for fetal tachycardia. Twelve were cases of supraventricular tachycardia, eight of atrial flutter, and three cases in which the rhythm varied between supraventricular tachycardia and atrial flutter. In 11 cases the fetus had developed non-immune fetal hydrops before referral; 12 cases were non-hydropic at referral but one of this group of fetuses became hydropic during treatment. No relation was found between the rate or type of arrhythmia and the presence or absence of intrauterine heart failure. One non-hydropic infant was delivered electively prematurely. Maternal antiarrhythmic treatment was instituted in the remaining 22 cases. Conversion of the arrhythmia was achieved with digoxin alone in five cases and with a combination of digoxin and verapamil in nine. Control of the arrhythmia was achieved in seven of the 10 non-hydropic fetuses, and all were delivered at term with no deaths. Of the 12 hydropic fetuses, control was achieved in seven. Only three of the hydropic fetuses were delivered close to term. There were two deaths, both in the hydropic group. Of the whole group, five neonates suffered severe complications of prematurity. In this series the main benefit of treatment appeared to be in prolonging gestation of those hydropic fetuses in which conversion was achieved.
在1980年至1987年期间,对23例孕周为22 - 38周的胎儿心动过速病例进行了调查。其中12例为室上性心动过速,8例为心房扑动,3例心律在室上性心动过速和心房扑动之间变化。11例胎儿在转诊前已出现非免疫性胎儿水肿;12例转诊时未出现水肿,但这组胎儿中有1例在治疗期间出现水肿。未发现心律失常的速率或类型与宫内心力衰竭的有无之间存在关联。1例未出现水肿的婴儿被选择性地提前分娩。其余22例实施了母体抗心律失常治疗。5例仅用洋地黄实现了心律失常的转复,9例用洋地黄和维拉帕米联合治疗实现了转复。10例未出现水肿的胎儿中有7例心律失常得到控制,所有这些胎儿均足月分娩,无死亡病例。12例出现水肿的胎儿中有7例心律失常得到控制。只有3例出现水肿的胎儿接近足月分娩。有2例死亡,均在出现水肿的胎儿组中。在整个组中,5例新生儿出现严重的早产并发症。在该系列中,治疗的主要益处似乎在于延长那些心律失常得以转复的出现水肿的胎儿的孕周。