非洲猪瘟病毒活疫苗的研究进展。
Research progress on live attenuated vaccine against African swine fever virus.
机构信息
State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, 730046, PR China.
State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, 730046, PR China.
出版信息
Microb Pathog. 2021 Sep;158:105024. doi: 10.1016/j.micpath.2021.105024. Epub 2021 Jun 3.
African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by African swine fever virus (ASFV) in domestic pigs and various wild boars, with a mortality rate up to 100%. ASF was first discovered in 1921 in Kenya. ASFV has a large genome and complex immune escape mechanism creating difficulties in the production of vaccines. Recently, remarkable advances have been made in vaccine development all over the world especially in live-attenuated vaccine. This article aims to review the research progress of ASF attenuated live vaccines in order to provide a reference for the development of vaccines for this disease.
非洲猪瘟（ASF）是由非洲猪瘟病毒（ASFV）引起的家猪和各种野猪的一种急性、出血性和高度传染性疾病，死亡率高达 100%。ASF 于 1921 年首次在肯尼亚发现。ASFV 具有庞大的基因组和复杂的免疫逃逸机制，给疫苗的生产带来了困难。最近，全世界在疫苗开发方面取得了显著进展，特别是在减毒活疫苗方面。本文旨在综述 ASF 减毒活疫苗的研究进展，以期为该病疫苗的开发提供参考。
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