Department of Spine Surgery, Changhai Hospital, Naval Medical University, Shanghai, China.
Department of Radiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Med Hypotheses. 2021 Jul;152:110616. doi: 10.1016/j.mehy.2021.110616. Epub 2021 May 27.
The pathogenesis of Adolescent Idiopathic Scoliosis (AIS) remains unclear. Previous research proposed that ligament laxity is a clinical feature that can be easily overlooked in patients with AIS. We speculated a new hypothesis which is an improvement of our three-dimensional spring model hypothesis of AIS pathogenesis. The tethered string in the spring model stimulates the spinal ligament instead of spinal cord. Spinal overgrowth in the adolescent age leads to higher tension of posterior spinal ligament. And the ligament laxity leads to lower tension of anterior spinal ligament. This uncoupled anterior and posterior spinal ligament tension maybe the key cause of AIS.
青少年特发性脊柱侧凸（AIS）的发病机制尚不清楚。既往研究提出，韧带松弛是 AIS 患者容易忽略的临床特征。我们推测了一个新的假说，这是我们 AIS 发病机制三维弹簧模型假说的改进。弹簧模型中的系绳刺激脊柱韧带而不是脊髓。青少年时期脊柱过度生长导致后脊柱韧带张力增加。韧带松弛导致前脊柱韧带张力降低。这种前后脊柱韧带张力的不耦合可能是 AIS 的关键原因。
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