Scoliosis Research Center, Orthopedic Department, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Med Hypotheses. 2009 Nov;73(5):709-13. doi: 10.1016/j.mehy.2009.02.046. Epub 2009 Jun 3.
The pathogenesis of adolescent idiopathic scoliosis (AIS) has been the subject of many studies, but remains little understood. Previous work has shown that there is a correlation between the uncoupled spinal neuro-osseous growth and AIS. We believe that this uncoupled spinal neuro-osseous growth may also contribute to formation of normal curvature of the spine in the sagittal plane during the childhood. We speculate a three-dimensional spring model to better understand our hypothesis. The normal curvature of the spine, the uncoupled spinal neuro-osseous growth, and the overgrowth of the spine in the puberty may be the crucial factors in the pathogenesis of AIS.
青少年特发性脊柱侧凸（AIS）的发病机制一直是许多研究的主题，但仍知之甚少。之前的研究表明，脊柱神经-骨骼生长的不耦合与 AIS 之间存在相关性。我们认为这种脊柱神经-骨骼生长的不耦合也可能导致儿童脊柱矢状面正常曲度的形成。我们推测了一个三维弹簧模型来更好地理解我们的假设。脊柱的正常曲度、脊柱神经-骨骼生长的不耦合以及青春期脊柱的过度生长可能是 AIS 发病机制的关键因素。
