脊髓心血管位点的血管紧张素受体。

Angiotensin receptors at the spinal cardiovascular loci.

作者信息

Pant K K, Gurtu S

机构信息

Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.

出版信息

Brain Res. 1988 Jun 28;454(1-2):400-3. doi: 10.1016/0006-8993(88)90846-3.

DOI:10.1016/0006-8993(88)90846-3

PMID:3409024

Abstract

Intrathecal injection of graded doses of angiotensin elicited a significant, dose-related rise in blood pressure without affecting heart rate. Tachyphylaxis appeared with repeated intrathecal injections but intravenous angiotensin could elicit pressor effects at this stage. Intrathecal administration of saralasin per se, did not affect resting heart rate or blood pressure. However, pretreatment with saralasin completely antagonized the intrathecal angiotensin-induced rise in blood pressure without significantly altering the effect of intravenous angiotensin. A facilitatory role for blood pressure regulation is suggested for the angiotensin receptors at the spinal cardiovascular loci.

摘要

鞘内注射不同剂量的血管紧张素可引起血压显著升高且呈剂量依赖性，而心率不受影响。重复鞘内注射会出现快速耐受现象，但在此阶段静脉注射血管紧张素仍可产生升压效应。单独鞘内注射沙拉新对静息心率或血压无影响。然而，沙拉新预处理可完全拮抗鞘内注射血管紧张素引起的血压升高，而对静脉注射血管紧张素的效应无显著影响。提示脊髓心血管位点的血管紧张素受体在血压调节中起促进作用。