Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Department of Microbiology, AIIMS, Bilaspur, Himachal Pradesh, India.
Indian J Med Microbiol. 2021 Jul;39(3):370-372. doi: 10.1016/j.ijmmb.2021.05.013. Epub 2021 Jun 2.
On analyzing the drug susceptibility profile of 151 clinical isolates collected from patients of tuberculous meningitis (TBM) over 10 years, we reflect on few lessons learnt from the trend of susceptibility profile - drug resistance was not uncommon, fluoroquinolone resistance was observed even among otherwise susceptible isolates and hetero-resistance was observed against rifampicin, isoniazid and also fluoroquinolones. In the midst of widening gap between incidence of drug resistant TBM and availability of effective drugs, our data suggests that universal testing for drug resistance, careful choice of drugs having optimal penetration and individualized therapy should form important pillars of TBM management.
对 10 年来从结核性脑膜炎 (TBM) 患者中收集的 151 株临床分离株的药敏谱进行分析后，我们反思了从药敏谱趋势中得到的一些经验教训——耐药性并不罕见，即使在其他敏感的分离株中也观察到氟喹诺酮类药物耐药，异烟肼和氟喹诺酮类药物也存在交叉耐药。在耐药性 TBM 的发病率与有效药物的可获得性之间差距不断扩大的情况下，我们的数据表明，普遍的耐药性检测、选择具有最佳渗透作用的药物和个体化治疗应成为 TBM 管理的重要支柱。
Zotero 插件