Nagarathna S, Rafi W, Veenakumari H B, Mani R, Satishchandra P, Chandramuki A
Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Int J Tuberc Lung Dis. 2008 Jan;12(1):105-7.
Drug-resistant tuberculosis is an increasing problem worldwide. There are few reports of drug susceptibility patterns of Mycobacterium tuberculosis isolated from cases of tuberculous meningitis. A 5-year retrospective study aimed at analysing the drug susceptibility profile of M. tuberculosis isolated from tuberculous meningitis cases was conducted. A total of 366 isolates were analysed. Among these, 301 (82.2%) were sensitive to all the four primary drugs tested, while 65 (17.8%) showed resistance. There were 46 (12.5%) isolates resistant to isoniazid (INH), while 9 (2.4%) demonstrated multidrug resistance. These data suggest that multidrug resistance in tuberculous meningitis is not yet a serious problem. However, a periodic review is required to ascertain the global incidence of drug-resistant tuberculous meningitis.
耐药结核病在全球范围内是一个日益严重的问题。关于从结核性脑膜炎病例中分离出的结核分枝杆菌药敏模式的报道很少。开展了一项为期5年的回顾性研究，旨在分析从结核性脑膜炎病例中分离出的结核分枝杆菌的药敏情况。共分析了366株分离菌。其中，301株（82.2%）对所有四种测试的一线药物敏感，而65株（17.8%）显示耐药。有46株（12.5%）分离菌对异烟肼（INH）耐药，而9株（2.4%）表现出多重耐药。这些数据表明，结核性脑膜炎中的多重耐药尚未成为一个严重问题。然而，需要定期进行评估以确定耐药结核性脑膜炎的全球发病率。
