衰老的营养认知神经科学：关注类胡萝卜素与认知衰弱
Nutritional cognitive neuroscience of aging: Focus on carotenoids and cognitive frailty.
作者信息
Polidori M Cristina, Stahl Wilhelm, Griffiths Helen R
机构信息
Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany.
出版信息
Redox Biol. 2021 Aug;44:101996. doi: 10.1016/j.redox.2021.101996. Epub 2021 May 8.
The term "nutritional cognitive neuroscience" was recently established to define a research field focusing on the impact of nutrition on cognition and brain health across the life span. In this overview, we summarize the robust evidence on the role of carotenoids as micronutrients with different biological properties in persons with cognitive (pre)frailty. As neurodegenerative processes during aging occur in a continuum from brain aging to dementia, we propose the name "nutritional cognitive neuroscience of aging" to define research on the role of nutrition and micronutrients in cognitive frailty. Further studies are warranted which integrate carotenoid interventions in multidomain, personalized lifestyle strategies.
“营养认知神经科学”这一术语最近被确立，用于定义一个专注于营养对人一生认知和大脑健康影响的研究领域。在本综述中，我们总结了关于类胡萝卜素作为具有不同生物学特性的微量营养素在认知（前期）衰弱人群中作用的有力证据。由于衰老过程中的神经退行性变是一个从大脑衰老到痴呆的连续过程，我们提出“衰老的营养认知神经科学”这一名称，以定义关于营养和微量营养素在认知衰弱中作用的研究。有必要进行进一步的研究，将类胡萝卜素干预纳入多领域、个性化的生活方式策略中。
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