姜黄素在骨关节炎中的软骨保护和抗关节炎作用：一项体外和体内研究。
Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study.
机构信息
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
出版信息
Eur J Pharmacol. 2021 Sep 5;906:174232. doi: 10.1016/j.ejphar.2021.174232. Epub 2021 Jun 4.
Osteoarthritis (OA) is a common degenerative joint disease blamed for pain and disability in the elderly. Galangin (GAL) is a natural flavonoid that exhibits anti-inflammatory properties in various inflammation diseases. However, the role of GAL in OA remains unclear. In this study, we investigate the role of GAL in the progress and development of OA in vitro and vivo. The results showed that IL-1β exposure resulted in increased expression of iNOS, COX-2, MMP1, MMP3, MMP13 and ADAMTS5 in rat chondrocytes. However, co-treatment with GAL significantly decreased theses inflammatory cytokines and catabolic factors expression. In addition, GAL reduced IL-1β-induced degradation of collagen II and aggrecan in chondrocytes. Furthermore, GAL significantly suppressed IL-1β-induced Akt phosphorylation and NF-κB activation in rat chondrocytes. In vivo, intra-articular injection of GAL could also reduce the cartilage degradation in the ACLT rat model. This study reveals galangin may act as a promising novel agent in the treatment of OA.
骨关节炎（OA）是一种常见的退行性关节疾病，可导致老年人疼痛和残疾。高良姜素（GAL）是一种天然类黄酮，在各种炎症性疾病中具有抗炎作用。然而，GAL 在 OA 中的作用尚不清楚。在这项研究中，我们研究了 GAL 在 OA 的体外和体内进展和发展中的作用。结果表明，IL-1β 暴露导致大鼠软骨细胞中 iNOS、COX-2、MMP1、MMP3、MMP13 和 ADAMTS5 的表达增加。然而，GAL 联合治疗显著降低了这些炎症细胞因子和分解代谢因子的表达。此外，GAL 减少了 IL-1β 诱导的软骨细胞中胶原 II 和聚集蛋白聚糖的降解。此外，GAL 显著抑制了 IL-1β 诱导的大鼠软骨细胞中 Akt 磷酸化和 NF-κB 激活。在体内，关节内注射 GAL 也可以减少 ACLT 大鼠模型中的软骨降解。这项研究表明，高良姜素可能是治疗 OA 的一种有前途的新型药物。
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