University of Copenhagen, BRIC Biotech Research & Innovation Centre, Lund Group, 2200 Copenhagen, Denmark.
Biomed J. 2021 Jun;44(3):227-234. doi: 10.1016/j.bj.2021.05.006. Epub 2021 Jun 4.
This issue of the Biomedical Journal tells us about the risks of electronic cigarette smoking, variations of SARS-CoV-2 and ACE2, and how COVID-19 affects the gastrointestinal system. Moreover, we learn that cancer immunotherapy seems to work well in elderly patients, how thyroid hormones regulate noncoding RNAs in a liver tumour context, and that G6PD is a double-edged sword of redox signalling. We also discover that Perilla leaf extract could inhibit SARS-CoV-2, that artificial neural networks can diagnose COVID-19 patients and predict vaccine epitopes on the Epstein-Barr Virus, and that men and women have differential inflammatory responses to physical effort. Finally, the surgical strategies for drug-resistant epilepsy, computer-supervised double-jaw surgery, dental pulp stem cell motility, and the restitution of the brain blood supply after atherosclerotic stroke are discussed.
本期《生物医学期刊》告诉我们电子烟吸烟的风险、SARS-CoV-2 和 ACE2 的变异，以及 COVID-19 如何影响胃肠道系统。此外，我们了解到癌症免疫疗法似乎对老年患者有效，甲状腺激素如何在肝肿瘤环境中调节非编码 RNA，以及 G6PD 是氧化还原信号的双刃剑。我们还发现紫苏叶提取物可以抑制 SARS-CoV-2，人工神经网络可以诊断 COVID-19 患者并预测 Epstein-Barr 病毒上的疫苗表位，以及男性和女性对体力活动有不同的炎症反应。最后，讨论了耐药性癫痫的手术策略、计算机监督的双颌手术、牙髓干细胞运动，以及动脉粥样硬化性中风后大脑血液供应的恢复。
