LeBaron S, Zeltzer P M, Zeltzer L K, Scott S E, Marlin A E
University of Texas Health Science Center, San Antonio.
Cancer. 1988 Sep 15;62(6):1215-22. doi: 10.1002/1097-0142(19880915)62:6<1215::aid-cncr2820620629>3.0.co;2-c.
To determine the quality of survival for children with posterior fossa tumors, comprehensive neuropsychological, behavioral, and academic assessment and physician ratings of functional status were obtained on 15 brain tumor patients (ages 6-19 years) at a median of 20 months post-diagnosis. More than 50% of the children (whether irradiated or not) experienced major problems in academic, motor, sensory, cognitive, and emotional function. All but two children were reported by teachers to be "slow workers," and four of 15 patients were able to maintain their school work in regular classes. Although 80% of the patients were rated by physicians as having "excellent" or "good" functional status, no relationship was found between these global ratings and psychometric measures. Although the affected site was the posterior fossa, deficits also involved higher cortical function. These findings indicate the need for further evaluation of treatment effects and the provision of intervention for survivors.
为了确定后颅窝肿瘤患儿的生存质量，在诊断后中位时间20个月时，对15例脑肿瘤患者（年龄6 - 19岁）进行了全面的神经心理学、行为学和学业评估以及医生对功能状态的评级。超过50%的儿童（无论是否接受过放疗）在学业、运动、感觉、认知和情感功能方面存在重大问题。教师报告称，除两名儿童外，其他所有儿童都是“学习进度缓慢者”，15名患者中有4名能够在常规班级维持学业。尽管80%的患者被医生评定为功能状态“优秀”或“良好”，但在这些总体评级与心理测量指标之间未发现相关性。尽管病变部位在后颅窝，但缺陷也涉及更高层次的皮质功能。这些发现表明需要进一步评估治疗效果并为幸存者提供干预措施。
