Faustino Isabel Schausltz Pereira, Fernandes Patrícia Maria, Pontes Hélder Antônio Rebelo, Mosqueda-Taylor Adalberto, Santos-Silva Alan Roger, Vargas Pablo Agustin, Lopes Marcio Ajudarte
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
²Department of Oral Pathology, Federal University of Pará, Belém, Brazil.
J Oral Pathol Med. 2021 Jul;50(6):565-571. doi: 10.1111/jop.13207. Epub 2021 Jun 20.
Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation and infiltration of histiocytic cells.
This review focused on the main aspects associated with LCH.
LCH can involve single or multiple organs and systems, with bone and skin being the most commonly affected sites. Regarding skeletal manifestations, the jawbones are involved in about 20%-30% of all cases. Such lesions may present as unilocular or multilocular images mainly affecting the posterior mandible. Oral soft tissue lesions may also occur, with the gingiva and hard palate being the most frequently affected sites.
The diagnosis and management of LCH are challenging, requiring a multidisciplinary approach, with dentists playing a central role since oral manifestations can be the first sign of the condition.
朗格汉斯细胞组织细胞增多症（LCH）是一种罕见的疾病，其特征为组织细胞异常增殖和浸润。
本综述聚焦于与LCH相关的主要方面。
LCH可累及单个或多个器官及系统，骨骼和皮肤是最常受累的部位。在骨骼表现方面，约20%-30%的病例累及颌骨。此类病变可呈现为单房或多房影像，主要影响下颌骨后部。口腔软组织病变也可能发生，牙龈和硬腭是最常受累的部位。
LCH的诊断和管理具有挑战性，需要多学科方法，由于口腔表现可能是该病的首发症状，牙医起着核心作用。
