Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Division of Oncology, Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Breast Dis. 2021;40(S1):S63-S70. doi: 10.3233/BD-219009.
Phyllodes tumors (PTs) are rare fibroepithelial breast tumors with diverse biological behavior.
This study aimed to analyze the characteristics, management, and outcome of phyllodes tumors.
Patients diagnosed with PTs in our institution from January 2013 to December 2017 were identified retrospectively by the ICD-10 code. Data were collected from medical records. The diagnosis of this tumor was based on histopathological results. Variables analyzed included age, tumor site, surgical option, axillary lymph nodes, chemotherapy and radiotherapy, metastases, disease-free survival (DFS), and overall survival (OS) rate.
Sixty-nine cases of PTs were diagnosed during the period, of which 31 were benign, 38 were malignant, and 1 was a case of bilateral metachronous tumors. We did not find any borderline pathologic cases. The patient's ages ranged from 20 to 71 years, with the highest number of cases (28) from the 40-49-year-old age group. The majority of patients (42) had PT on the right side. Simple mastectomy was the most performed treatment, with 53 such cases, including both benign and malignant. The axillary staging was carried out in 16 cases, of which none had nodal metastasis. Ten cases received chemotherapy, and 16 cases of malignant phyllodes received postoperative radiotherapy. We found 4 cases with distant metastases and 5 cases that developed local recurrence. The DFS rate reached 92.75%, and the overall 5-year survival rate was 84.21%.
The incidence of PTs is highest in women in the 3rd and fourth decades of age. Simple mastectomy and wide excision are the treatments of choice, with a low recurrence rate in both benign and malignant PTs cases.
叶状肿瘤（PTs）是一种罕见的具有多种生物学行为的纤维上皮性乳腺肿瘤。
本研究旨在分析叶状肿瘤的特征、治疗方法和结局。
通过国际疾病分类第 10 版（ICD-10）代码，回顾性地确定了 2013 年 1 月至 2017 年 12 月期间在我院诊断为 PTs 的患者。从病历中收集数据。该肿瘤的诊断基于组织病理学结果。分析的变量包括年龄、肿瘤部位、手术选择、腋窝淋巴结、化疗和放疗、转移、无病生存（DFS）和总生存（OS）率。
在此期间诊断出 69 例 PTs，其中 31 例为良性，38 例为恶性，1 例为双侧同时性肿瘤。我们未发现任何交界性病理病例。患者年龄为 20-71 岁，其中 40-49 岁年龄组的病例最多（28 例）。大多数患者（42 例）的 PT 位于右侧。最常进行的治疗是单纯乳房切除术，包括良性和恶性，共有 53 例。对 16 例患者进行了腋窝分期，其中无一例淋巴结转移。10 例患者接受了化疗，16 例恶性叶状肿瘤患者接受了术后放疗。我们发现有 4 例远处转移和 5 例局部复发。DFS 率达到 92.75%，整体 5 年生存率为 84.21%。
PTs 的发病率在 30 至 40 岁的女性中最高。单纯乳房切除术和广泛切除术是首选的治疗方法，良性和恶性 PTs 病例的复发率均较低。
