Yoshioka Daisuke, Iwata Masaaki, Kaneko Koichi
Division of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan.
Department of Psychiatry, National Hospital Organization Tottori Medical Center, Tottori, Japan.
Front Psychiatry. 2021 May 19;12:641474. doi: 10.3389/fpsyt.2021.641474. eCollection 2021.
Dissociative stupor is a common psychiatric disease lacking an established standard treatment. The lack of therapeutic options may be due to the spontaneous and quick complete remission of most patients. However, since some patients experience multiple relapses and prolonged stupor, investigating potential prevention and treatment options is critical. We reported the case of a 61-year-old Japanese woman who presented with intermittent dissociative stupor for several months. Despite her prolonged symptoms, the administration of lorazepam, escitalopram, and aripiprazole, which selectively enhance GABAergic and serotoninergic activity, improved her stupor and prevented relapse. These findings may help with the treatment of persistent dissociative stupor.
分离性木僵是一种常见的精神疾病，目前尚无既定的标准治疗方法。缺乏治疗选择可能是由于大多数患者会自发且迅速地完全缓解。然而，由于一些患者会多次复发且木僵状态持续时间较长，因此研究潜在的预防和治疗方法至关重要。我们报告了一例61岁日本女性的病例，该患者出现间歇性分离性木僵数月。尽管她的症状持续时间较长，但使用劳拉西泮、艾司西酞普兰和阿立哌唑（这些药物可选择性增强γ-氨基丁酸能和5-羟色胺能活性）改善了她的木僵状态并预防了复发。这些发现可能有助于治疗持续性分离性木僵。
