Maharaj Masha, Heslop Lucille, Govender Trisha, Korowlay Nisaar, Singh Aviral, Choudhary Partha, Sathekge Mike
Department of Nuclear Medicine, Imaging and Therapy Centres of Excellence, Durban, KwaZulu Natal South Africa.
Durban Oncology Centre, West Ridge, Durban, South Africa.
Nucl Med Mol Imaging. 2021 Jun;55(3):136-140. doi: 10.1007/s13139-021-00696-5. Epub 2021 Apr 13.
Prostate-specific membrane antigen (PSMA)-directed radioligand therapy (PSMA-RLT) with lutetium-177 (Lu-PSMA) has been used in metastatic castrate-resistant prostate cancer (mCRPC), and retrospective data have shown this therapy to be favourably safe with attractive clinical responses. Re-challenge Lu-PSMA therapy in early responders has been shown to be safe and effective. We report the use of low-dose Taxol-based chemotherapy (modified dose 25 mg/m weekly × 6 weeks) as a radiosensitizer with re-challenge Lu-PSMA therapy (4 cycles). In a period of 3 years, the patient underwent a total of 8 cycles of Lu-PSMA with a cumulative dose of 51.8 GBq. All therapies were uneventful and well tolerated. There was a good response to re-challenge Lu-PSMA therapy and low-dose docetaxel (Taxol-Lu-PSMA) with no recorded tumour resistance.
使用镥-177(Lu-PSMA)进行的前列腺特异性膜抗原(PSMA)导向放射性配体疗法(PSMA-RLT)已应用于转移性去势抵抗性前列腺癌(mCRPC),回顾性数据表明该疗法安全性良好且临床反应可观。在早期缓解者中再次使用Lu-PSMA疗法已被证明是安全有效的。我们报告了使用低剂量基于紫杉醇的化疗(改良剂量25mg/m²每周×6周)作为放射增敏剂并再次使用Lu-PSMA疗法(4个周期)的情况。在3年的时间里,该患者总共接受了8个周期的Lu-PSMA治疗,累积剂量为51.8GBq。所有治疗过程均顺利且耐受性良好。再次使用Lu-PSMA疗法和低剂量多西他赛(Taxol-Lu-PSMA)有良好反应,未记录到肿瘤耐药情况。