Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Department of Orthodontics, Hangzhou Stomatology Hospital, Hangzhou, China.
Front Cell Infect Microbiol. 2021 May 21;11:637394. doi: 10.3389/fcimb.2021.637394. eCollection 2021.
To provide a dynamic description of the oral microbial composition in mothers with and without dental caries and their children aging 12-24 months.
A total of 20 pairs of mothers and their children aged 12 months were included and followed up at 18 and 24 months of age. Ten mothers with dental caries(MEG) and their children(CEG) were in the exposure group, and ten caries-free mothers(MCG) and their children(CCG)in control group. Supragingival plaque biofilm samples were collected and DNA was extracted for bacterial 16S rRNA gene sequencing.
A total of 18 pairs completed follow-ups. At a 3% divergence level, the number of common operational taxonomic units found between the mothers and children increased as the children aged. , , , , and accounted for more than 80% phyla of each group. A microbial community structure analysis showed that the differences between mothers and children were significant in all groups except for the MEG24 and CEG24 groups.
Oral microbiota of children was more like their mothers' with increasing age, regardless of whether the mothers had dental caries. Mothers with dental caries may have a greater influence on the oral microbiota of children's than those without dental caries as children age.
描述有龋和无龋母亲及其 12-24 月龄婴儿口腔微生物组成的动态变化。
共纳入 20 对年龄为 12 个月的母婴，并在 18 和 24 个月时进行随访。10 名患有龋病的母亲（MEG）及其子女（CEG）为暴露组，10 名无龋病的母亲（MCG）及其子女（CCG）为对照组。采集龈上菌斑生物膜样本并提取 DNA 进行细菌 16S rRNA 基因测序。
共 18 对完成随访。在 3%的分歧水平上，随着儿童年龄的增长，母亲和儿童之间的共有操作分类单元数量增加。在所有组中， 、 、 、 和 占每个组的 80%以上。微生物群落结构分析表明，除 MEG24 和 CEG24 组外，各组母亲与儿童之间的差异均有统计学意义。
无论母亲是否有龋病，儿童的口腔微生物群随着年龄的增长越来越像他们的母亲。随着儿童年龄的增长，有龋病的母亲对儿童口腔微生物群的影响可能比无龋病的母亲更大。
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