Department of Biochemistry, Indian Institute of Science, Bangalore, India.
Bioessays. 2021 Aug;43(8):e2000311. doi: 10.1002/bies.202000311. Epub 2021 Jun 7.
Genotoxic stress leads to DNA damage which can be detrimental to the cell. A well-orchestrated cellular response is mounted to manage and repair the genotoxic stress-induced DNA damage. Our understanding of genotoxic stress response is derived mainly from studies focused on transcription, mRNA splicing, and protein turnover. Surprisingly not as much is understood about the role of mRNA translation and decay in genotoxic stress response. This is despite the fact that regulation of gene expression at the level of mRNA translation and decay plays a critical role in a myriad of cellular processes. This review aims to summarize some of the known findings of the role of mRNA translation and decay by focusing on two categories of examples. We discuss examples of mRNA whose fates are regulated in the cytoplasm and RNA-binding proteins that regulate mRNA fates in response to genotoxic stress.
遗传毒性应激会导致 DNA 损伤，这可能对细胞有害。细胞会启动精心协调的反应来管理和修复遗传毒性应激引起的 DNA 损伤。我们对遗传毒性应激反应的理解主要来自于专注于转录、mRNA 剪接和蛋白质周转的研究。令人惊讶的是，对于 mRNA 翻译和降解在遗传毒性应激反应中的作用，我们的了解并不多。尽管事实上，mRNA 翻译和降解水平的基因表达调控在无数细胞过程中起着关键作用。这篇综述旨在通过关注两类例子来总结 mRNA 翻译和降解作用的一些已知发现。我们讨论了细胞质中调节命运的 mRNA 以及响应遗传毒性应激调节 mRNA 命运的 RNA 结合蛋白的例子。
