Gonzalez-Rothi R J, Foresman G E, Block A J
Department of Medicine, University of Florida, College of Medicine, Gainesville.
Chest. 1988 Sep;94(3):531-8. doi: 10.1378/chest.94.3.531.
Patients with sleep apnea syndrome (SAS) show cardiac dysrhythmias in association with cyclical nocturnal hypoxemia; are they at risk of dying during sleep? To assess this claim, we reviewed the clinical course of 91 patients with polysomnographically documented SAS between July 1978 and June 1986. A control group was comprised of 35 patients who were referred with symptoms suggestive of SAS but had negative sleep studies. Follow-up was obtained by survey questionnaire. Nine of 91 SAS and four of 35 control patients had died by completion of the study. There were no statistically significant differences in mortality between the two groups. None of the SAS patients died in their sleep, but they reported a higher incidence of disability and vehicular mishaps than did control subjects. The findings in this study do not support the hypothesis that SAS patients are at increased risk of dying in their sleep.
睡眠呼吸暂停综合征（SAS）患者会出现与周期性夜间低氧血症相关的心律失常；他们有在睡眠中死亡的风险吗？为了评估这一说法，我们回顾了1978年7月至1986年6月间91例经多导睡眠图记录确诊为SAS患者的临床病程。对照组由35例因疑似SAS症状就诊但睡眠检查结果为阴性的患者组成。通过调查问卷进行随访。到研究结束时，91例SAS患者中有9例死亡，35例对照患者中有4例死亡。两组之间的死亡率没有统计学上的显著差异。没有一例SAS患者在睡眠中死亡，但他们报告的残疾和车辆事故发生率高于对照组。本研究结果不支持SAS患者在睡眠中死亡风险增加的假设。
