利比亚的黎波里分离的耐碳青霉烯类鲍曼不动杆菌的序列类型多样性和适应度代价的影响。
Diversity of Sequence Types and Impact of Fitness Cost among Carbapenem-Resistant Acinetobacter baumannii Isolates from Tripoli, Libya.
机构信息
Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon.
出版信息
Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0027721. doi: 10.1128/AAC.00277-21.
Abstract
We investigated the molecular epidemiology of 21 carbapenem-resistant Acinetobacter baumannii isolates from Libya and assessed their relative fitness. Core genome multilocus sequence typing (MLST) revealed five interhospital transmission clusters. Three clusters were associated with the international clones (IC) IC1, IC2, and IC7. Carbapenem-resistance was associated with , , or . Compared to that of A. baumannii DSM 30008, the doubling time was similar over 10 h, but after 16 h, half the isolates grew to higher densities, suggesting a fitness advantage.
摘要
我们调查了来自利比亚的 21 株碳青霉烯类耐药鲍曼不动杆菌的分子流行病学情况，并评估了它们的相对适应性。核心基因组多位点序列分型（MLST）显示有五个院内传播集群。其中三个集群与国际克隆（IC）IC1、IC2 和 IC7 有关。碳青霉烯类耐药性与、或有关。与 A.baumannii DSM 30008 相比，倍增时间在 10 小时内相似，但在 16 小时后，一半的分离株生长到更高的密度，这表明存在适应性优势。
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