Hematologic Disease Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Xinjiang Uygur Autonomous Region Research Institute of Hematology, Urumqi, China.
Ann Hum Biol. 2021 Mar;48(2):133-141. doi: 10.1080/03014460.2021.1913223.
The killer cell immunoglobulin-like receptor (KIR), which mediates the killing function of NK cells, is an attractive candidate for adoptive cellular therapy. The ethnic distribution for China provides a unique opportunity to investigate KIR gene distribution.
The aim of this study was to explore the relationship between population history and the rapidly evolving KIR genetic diversity.
8050 Chinese donors from 184 hospitals were included to analyse frequency, haplotype, and B-content data of 16 KIR genes, by PCR-SSP for KIR genotyping.
KIR gene carrier frequencies were found similar to those observed in other studies on Han, but different from Thais, Japanese, Africans, and populations of West Eurasian ancestry. High-frequency KIR genotype profiles found in the present population were consistent with other studies on Han populations but different from those conducted on other cohorts. The majority of our cohort carried group A KIR gene motifs. Additionally, populations with similar geographic locations in China were shown clustered together, while Hainan and Xinjiang provinces were slightly separated from these.
The distribution of KIR genes varies by geographic region, and different ethnic groups may be a confounding factor of KIR diversity.
杀伤细胞免疫球蛋白样受体（KIR）介导 NK 细胞的杀伤功能，是细胞过继治疗的一个有吸引力的候选者。中国的种族分布为研究 KIR 基因分布提供了一个独特的机会。
本研究旨在探讨种群历史与快速进化的 KIR 遗传多样性之间的关系。
纳入了来自 184 家医院的 8050 名中国供体，通过 PCR-SSP 对 16 个 KIR 基因进行 KIR 基因分型，分析频率、单倍型和 B 含量数据。
KIR 基因携带者频率与其他汉族研究观察到的频率相似，但与泰国人、日本人、非洲人以及西欧亚人群不同。本研究人群中发现的高频 KIR 基因型与其他汉族人群的研究一致，但与其他队列的研究不同。本研究人群中大多数携带 A 组 KIR 基因基序。此外，中国地理位置相似的人群聚类在一起，而海南和新疆与其他人群略有分离。
KIR 基因的分布因地理位置而异，不同的民族可能是 KIR 多样性的一个混杂因素。
