新生儿高胆红素血症脑损伤振幅整合脑电图、神经元特异性烯醇化酶和 S100B 的变化及其意义。

Changes in amplitude-integrated electroencephalography, neuron-specific enolase, and S100B in neonates with brain injury induced by neonatal hyperbilirubinemia and their significance.

机构信息

Department of Pediatrics, Xuzhou Central Hospital (Xuzhou Clinical School of Xuzhou Medical University), Xuzhou, China.

出版信息

Brain Inj. 2021 Jul 3;35(8):943-948. doi: 10.1080/02699052.2021.1931449. Epub 2021 Jun 7.

DOI:10.1080/02699052.2021.1931449

PMID:34097553

Abstract

OBJECTIVE

To explore the changes in amplitude-integrated electroencephalography (aEEG), neuron-specific enolase (NSE), and S100B in neonates with brain injury induced by neonatal hyperbilirubinemia (NHB).

METHODS

67 neonates with brain injury induced by NHB admitted to our hospital from March 2016 to October 2018 were included in a brain injury group (BIG), and 82 neonates with NHB but without brain injury in our hospital during the same period were included in a non-BIG. The two groups were compared regarding the rates of normal and abnormal aEEG results.

RESULTS

The proportion of normal aEEG results in the BIG was significantly lower than that in the non-BIG, and the proportion of moderately and severely abnormal aEEG results in the BIG were both significantly higher than those in the non-BIG. The BIG showed significantly higher NSE and S100B levels than those of the non-BIG. The ROC curve for predicting prognosis showed that the AUC of aEEG, NSE, S100B, and the combined detection are 0.780, 0.754, 0.743, 0.788. The AUC > 0.700 indicated a good predictive value for the prognosis.

CONCLUSION

The combination of aEEG, NSE, and S100B has good value in diagnosing injury induced by NHB and can predict prognosis moderately well.

摘要

目的

探讨新生儿高胆红素血症（NHB）所致脑损伤患儿振幅整合脑电图（aEEG）、神经元特异性烯醇化酶（NSE）和 S100B 的变化。

方法

选取 2016 年 3 月至 2018 年 10 月我院收治的 67 例 NHB 合并脑损伤患儿为脑损伤组（BIG），同期我院收治的 82 例 NHB 无脑损伤患儿为非脑损伤组（非 BIG）。比较两组 aEEG 结果正常和异常的比例。

结果

BIG 组 aEEG 结果正常比例明显低于非 BIG 组，中度及重度异常 aEEG 结果比例明显高于非 BIG 组。BIG 组 NSE 和 S100B 水平明显高于非 BIG 组。预测预后的 ROC 曲线显示，aEEG、NSE、S100B 及联合检测的 AUC 分别为 0.780、0.754、0.743、0.788。AUC>0.700 提示对预后有较好的预测价值。