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基于非特异性症状的初级保健中较少见癌症诊断路径:服务评估。

Non-specific symptoms-based pathways for diagnosing less common cancers in primary care: a service evaluation.

机构信息

Cancer Research UK, London.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford.

出版信息

Br J Gen Pract. 2021 Oct 28;71(712):e846-e853. doi: 10.3399/BJGP.2020.1108. Print 2021 Nov.

Abstract

BACKGROUND

Although less common cancers account for almost half of all cancer diagnoses in England, their relative scarcity and complex presentation, often with non-specific symptoms, means that patients often experience multiple primary care consultations, long times to diagnosis, and poor clinical outcomes. An urgent referral pathway for non-specific symptoms, the Multidisciplinary Diagnostic Centre (MDC), may address this problem.

AIM

To examine the less common cancers identified during the MDC pilots and consider whether such an approach improves the diagnosis of these cancers.

DESIGN AND SETTING

A service evaluation of five MDC pilot projects in England from December 2016 to March 2019.

METHOD

Data items were collected by pilot sites in near-real time, based mainly on the English cancer outcomes and services dataset, with additional project-specific items. Simple descriptive and comparative statistics were used, including χ tests for proportions and -tests for means where appropriate.

RESULTS

From 5134 referrals, 378 cancers were diagnosed, of which 218 (58%) were less common. More than 30 different less common tumour types were diagnosed in this cohort. Of the MDC patients with less common cancers, 23% ( = 50) had ≥3 GP consultations before referral and, at programme level, a median time of 57 days was recorded from GP urgent referral to treatment for these tumour types.

CONCLUSION

A non-specific symptomatic referral route diagnoses a broad range of less common cancers, and can support primary care case management for patients with symptoms of possible cancer that do not qualify for a site-specific urgent referral.

摘要

背景

尽管在英格兰,较少见的癌症几乎占所有癌症诊断的一半,但由于其相对罕见且表现复杂,常伴有非特异性症状,这意味着患者通常会经历多次初级保健咨询、长时间的诊断和较差的临床结局。一种针对非特异性症状的紧急转诊途径——多学科诊断中心(MDC)——可能会解决这个问题。

目的

检查 MDC 试点中发现的较少见癌症,并探讨这种方法是否能改善这些癌症的诊断。

设计和设置

2016 年 12 月至 2019 年 3 月期间,对英格兰五个 MDC 试点项目进行的服务评估。

方法

试点单位主要基于英格兰癌症结局和服务数据集,结合项目特定的附加项目,近乎实时地收集数据项。使用简单的描述性和比较性统计数据,包括适当情况下的 χ 检验和 t 检验。

结果

从 5134 例转诊中,诊断出 378 例癌症,其中 218 例(58%)为较少见癌症。该队列中诊断出 30 多种不同的较少见肿瘤类型。在 MDC 较少见癌症患者中,23%(=50 例)在转诊前有≥3 次全科医生就诊,在项目层面,记录到这些肿瘤类型从全科医生紧急转诊到治疗的中位时间为 57 天。

结论

一种非特异性症状性转诊途径可诊断广泛的较少见癌症,并可为有非特异性癌症症状且不符合特定部位紧急转诊标准的患者提供初级保健病例管理支持。

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