Department of Oral Biology and Oral Pathology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
J Oral Pathol Med. 2021 Jul;50(6):540-547. doi: 10.1111/jop.13204. Epub 2021 Jun 24.
Immunosuppressed patients may be affected by a wide range of lymphoproliferative disorders (LPDs) ranging from self-limiting disorders to malignant lymphoid proliferations. These LPDs may be associated with systemic immune disorders, develop following organ transplantation or occur in the background of other forms of iatrogenic immunosuppression. Lymphotropic viruses, including Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV8), have been associated with the pathogenesis of distinct LPDs. The resulting classification of this group of disorders is very complex and inconsistent, with several new and emerging entities. Consequently, the diagnosis of an LPD, especially in an immunosuppressed patient, and its subsequent clinical management usually represent an important pitfall in daily clinical and pathology work. Therefore, the aim of this review was to use the available literature to describe the clinicopathological features of the most important benign LPDs that may be diagnosed in the head and neck region of immunosuppressed patients. Original clinical and microscopic images were used to illustrate some of these entities.
免疫抑制患者可能受到多种淋巴增殖性疾病（LPDs）的影响，范围从自限性疾病到恶性淋巴组织增生。这些 LPDs 可能与全身性免疫紊乱有关，在器官移植后发生或在其他形式的医源性免疫抑制背景下发生。淋巴亲嗜性病毒，包括 Epstein-Barr 病毒（EBV）和人类疱疹病毒-8（HHV8），与不同 LPDs 的发病机制有关。该组疾病的分类非常复杂且不一致，存在几种新出现的实体。因此，LPD 的诊断，特别是在免疫抑制患者中，以及随后的临床管理，通常是日常临床和病理工作中的一个重要陷阱。因此，本综述的目的是利用现有文献描述在免疫抑制患者的头颈部可能诊断出的最重要的良性 LPDs 的临床病理特征。使用原始的临床和显微镜图像来说明其中的一些实体。
