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COVID-19 后免疫的受者接受 SARS-CoV-2 阳性供者的肾移植。

Kidney transplantation from a SARS-CoV-2-positive donor for the recipients with immunity after COVID-19.

机构信息

Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.

Center of Anesthesiology and Intensive Care, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.

出版信息

Transpl Infect Dis. 2021 Aug;23(4):e13666. doi: 10.1111/tid.13666. Epub 2021 Jun 22.

DOI:10.1111/tid.13666
PMID:34097791
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8209852/
Abstract

The coronavirus (COVID-19) pandemic is evolving very quickly and has affected healthcare systems worldwide. Many uncertainties remain about transplantation from a SARS-CoV-2-positive donor as only a few cases have been reported. Here, we present the successful transplantation of 2 kidneys from a 52-year-old male donor with active (2 weeks of COVID-19-like symptoms and positive nasopharyngeal swab SARS-CoV-2 polymerase chain reaction on the day of organ recovery) SARS-CoV-2 disease. The immediate postoperative course of both recipients was uneventful. This case emphasizes that patients with SARS-CoV-2 may be safe organ donors.

摘要

冠状病毒(COVID-19)大流行发展非常迅速,已对全球医疗保健系统造成影响。由于仅报告了少数几例病例,因此对于来自 SARS-CoV-2 阳性供体的移植仍存在许多不确定性。在这里,我们介绍了 2 例成功移植的病例,供体为 52 岁男性,患有活动期 SARS-CoV-2 疾病(COVID-19 样症状持续 2 周,器官采集当天鼻咽拭子 SARS-CoV-2 聚合酶链反应阳性)。两名受者的术后即刻过程均无异常。此病例强调,患有 SARS-CoV-2 的患者可能是安全的器官供体。

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本文引用的文献

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Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection.人类肾脏是新型严重急性呼吸综合征冠状病毒 2 感染的靶器官。
Nat Commun. 2021 May 4;12(1):2506. doi: 10.1038/s41467-021-22781-1.
2
Reduced humoral response to mRNA SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients without prior exposure to the virus.肾移植受者在未接触过病毒的情况下,对 mRNA SARS-CoV-2 BNT162b2 疫苗的体液反应降低。
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3
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Am J Transplant. 2021 Aug;21(8):2913-2915. doi: 10.1111/ajt.16607. Epub 2021 May 7.
4
A call to routinely test lower respiratory tract samples for SARS-CoV-2 in lung donors.呼吁对肺捐赠者的下呼吸道样本进行SARS-CoV-2常规检测。
Am J Transplant. 2021 Jul;21(7):2623-2624. doi: 10.1111/ajt.16576. Epub 2021 Apr 1.
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Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients.mRNA 疫苗在实体器官移植受者中的单剂免疫原性。
JAMA. 2021 May 4;325(17):1784-1786. doi: 10.1001/jama.2021.4385.
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Donor to recipient transmission of SARS-CoV-2 by lung transplantation despite negative donor upper respiratory tract testing.供体肺移植受者 SARS-CoV-2 的传播,尽管供体上呼吸道检测为阴性。
Am J Transplant. 2021 Aug;21(8):2885-2889. doi: 10.1111/ajt.16532. Epub 2021 Mar 15.
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J Nephrol. 2020 Dec;33(6):1213-1218. doi: 10.1007/s40620-020-00789-y. Epub 2020 Jul 20.
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Osong Public Health Res Perspect. 2020 Jun;11(3):112-117. doi: 10.24171/j.phrp.2020.11.3.02.