Fuse Y, Tsuchihashi Y, Sugihara H, Kodama T, Takino T, Fujita S
Department of Pathology, Kyoto Prefectural University of Medicine, Japan.
Dig Dis Sci. 1988 Sep;33(9):1081-8. doi: 10.1007/BF01535782.
The healing process of cysteamine-induced duodenal ulcer was studied by [3H]thymidine autoradiography. After the development of ulcer in the duodenum, cell proliferation was markedly activated not only in the crypts but also in the Brunner's glands near the ulcer. In the initial stages of ulcer healing, they both contributed to form the surface covering regenerating epithelium. Granulation tissue also proliferated at the base of the ulcer. In later stages of ulcer healing, new crypts were formed in the floor of the ulcer. New villi regenerated from these crypts and Brunner's glands regenerated by proliferation in situ. The ulcer base then was completely covered with new villi and granulation tissue was replaced by dense fibrous connective tissue. The present study suggested that the Brunner's glands, together with the crypts of Lieberkühn, play an important role in the healing process of cysteamine-induced duodenal ulcer.
采用[3H]胸腺嘧啶核苷放射自显影术研究了半胱胺诱导的十二指肠溃疡的愈合过程。十二指肠溃疡形成后，不仅隐窝，而且溃疡附近的Brunner腺中的细胞增殖均显著激活。在溃疡愈合的初始阶段，它们共同形成覆盖再生上皮的表面。肉芽组织也在溃疡底部增殖。在溃疡愈合的后期，溃疡底部形成新的隐窝。从这些隐窝再生出新的绒毛，Brunner腺通过原位增殖而再生。然后溃疡底部完全被新的绒毛覆盖，肉芽组织被致密的纤维结缔组织取代。本研究表明，Brunner腺与Lieberkühn隐窝一起，在半胱胺诱导的十二指肠溃疡愈合过程中起重要作用。
