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10% 利多卡因喷雾在血气采样中的局部麻醉作用:一项随机、双盲、安慰剂对照研究。

10% Lidocaine spray as a local anesthetic in blood gas sampling: A randomized, double-blind, placebo-controlled study.

机构信息

Ataturk University School of Medicine, Clinical Research, Development and Design Application and Research Center, Erzurum, Turkey; Department of Emergency, School of Medicine, Ataturk University, Erzurum, Turkey.

Department of Emergency, School of Medicine, Ataturk University, Erzurum, Turkey.

出版信息

Am J Emerg Med. 2021 Nov;49:89-93. doi: 10.1016/j.ajem.2021.05.060. Epub 2021 May 28.

Abstract

AIM

Radial artery blood gas sampling is a very common procedure undertaken in the emergency department to evaluate respiratory and metabolic parameters. This intervention causes both anxiety and pain for the patient. Therefore, the current study aimed to examine the analgesic efficacy of lidocaine spray compared to a placebo during radial artery blood gas sampling.

METHODS

This study was conducted in the emergency department of a tertiary hospital with a randomized, double-blind, placebo-controlled design. A total of 144 patients were randomly divided into two groups: One group (n = 72) received 10% lidocaine spray and the other (n = 72) was the placebo group. The analgesic efficacy of the 10% lidocaine spray was compared with the placebo group using the Visual Analog Scale (VAS).

RESULTS

In the evaluation of the analgesic efficacy of the 10% lidocaine spray, the VAS score was 1.5 [interquartile range (IQR): 2.0] for the lidocaine group and 5 (IQR: 2.0) for the placebo group. The role of lidocaine spray in reducing pain was statistically significant compared to the placebo (p = 0.000).

CONCLUSION

In blood gas sampling, 10% lidocaine spray has analgesic efficacy. Therefore, we recommend the use of lidocaine spray while performing arterial blood gas sampling in emergency departments.

摘要

目的

桡动脉血气采样是急诊科评估呼吸和代谢参数的常用操作。这一干预措施会给患者带来焦虑和疼痛。因此,本研究旨在比较利多卡因喷雾与安慰剂在桡动脉血气采样时的镇痛效果。

方法

本研究在一家三级医院的急诊科进行,采用随机、双盲、安慰剂对照设计。共纳入 144 名患者,随机分为两组:一组(n=72)接受 10%利多卡因喷雾,另一组(n=72)为安慰剂组。采用视觉模拟评分(VAS)比较 10%利多卡因喷雾的镇痛效果。

结果

在评估 10%利多卡因喷雾的镇痛效果时,利多卡因组的 VAS 评分为 1.5(四分位距 [IQR]:2.0),安慰剂组为 5(IQR:2.0)。与安慰剂相比,利多卡因喷雾在减轻疼痛方面的作用具有统计学意义(p=0.000)。

结论

在血气采样中,10%利多卡因喷雾具有镇痛效果。因此,我们建议在急诊科进行动脉血气采样时使用利多卡因喷雾。

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