Zinchenko V A, Okulov L V, Gol'dshmid B Ia
Eksp Onkol. 1988;10(3):67-9.
Pathomorphological changes and indices of proliferative ability of tumour tissue in the esophagus and in the cardia are studied in 14 patients after and without the preoperative irradiation following its cultivation in diffuse chambers. The tissue was implanted into the abdominal cavity of 84 rats. Inhibition of the mitotic activity and synthesis of DNA in cell nuclei as well as the impairment of the formation processes typical of the unirradiated blastomas of the same histological structure in the tissue culture in vivo evidence for a pronounced effect of irradiation.
对14例患者在术前放疗前后的食管和贲门肿瘤组织进行了病理形态学改变及增殖能力指标的研究，这些组织在扩散小室中培养后植入84只大鼠的腹腔。体内组织培养中，细胞核有丝分裂活性和DNA合成受到抑制，以及具有相同组织结构的未受照射的母细胞瘤典型形成过程受到损害，这些都证明了放疗有显著效果。
