一名接受卡马西平治疗的患者发生致命性再生障碍性贫血。

Fatal aplastic anemia in a patient treated with carbamazepine.

作者信息

Franceschi M, Ciboddo G, Truci G, Borri A, Canal N

机构信息

Department of Neurology, University of Milan, Italy.

出版信息

Epilepsia. 1988 Sep-Oct;29(5):582-3. doi: 10.1111/j.1528-1157.1988.tb03765.x.

DOI:10.1111/j.1528-1157.1988.tb03765.x

PMID:3409843

Abstract

A case of fatal aplastic anemia due to carbamazepine treatment in an epileptic woman is reported. Despite concerns of fatal bone marrow toxicity due to carbamazepine, this is only the fourth documented and published report. Carbamazepine is a safe drug, but physicians and patients should be aware of the exceedingly rare but potentially fatal side effects, better prevented by clinical than by laboratory monitoring.

摘要

报告了一例癫痫女性因卡马西平治疗导致的致命性再生障碍性贫血病例。尽管存在卡马西平导致致命性骨髓毒性的担忧，但这仅是第四例有记录并发表的报告。卡马西平是一种安全的药物，但医生和患者应意识到其极其罕见但可能致命的副作用，通过临床监测比实验室监测能更好地预防这些副作用。