Ma Yubo, Wang Xiaowen, Li Ruoyu
Department of Dermatology and Venerology, Peking University First Hospital, China; Research Center for Medical Mycology, Peking University, China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, China; National Clinical Research Center for Skin and Immune Diseases, Beijing 100034, China.
Department of Dermatology and Venerology, Peking University First Hospital, China; Research Center for Medical Mycology, Peking University, China; Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, China; National Clinical Research Center for Skin and Immune Diseases, Beijing 100034, China.
Curr Opin Microbiol. 2021 Aug;62:93-102. doi: 10.1016/j.mib.2021.05.005. Epub 2021 Jun 4.
The incidence of skin fungal infections is increasing at an alarming rate worldwide, presenting a major challenge to health professionals. Cutaneous and subcutaneous fungal infections are caused by pathogenic or opportunistic organisms varying from mold, yeasts, to dimorphic fungi. Recently, skin fungal have been increasingly reported and studied, giving rise to crucial breakthroughs in etiology and pathogenesis. This review aims to summarize recent insights into the clinical and etiological characteristics of common skin fungal infections according to different fungal species, as well as remarkable advances in the immune mechanisms. We hope it will be helpful to understand these diverse skin fungal infections, and bring about the latest developments that may facilitate novel diagnostic and therapeutic approaches to improve the outcomes in these patients.
在全球范围内，皮肤真菌感染的发病率正以惊人的速度上升，这给卫生专业人员带来了重大挑战。皮肤和皮下真菌感染是由致病或机会性生物体引起的，这些生物体包括从霉菌、酵母到双相真菌等各种类型。最近，皮肤真菌的报道和研究越来越多，在病因学和发病机制方面取得了关键突破。本综述旨在根据不同真菌种类总结常见皮肤真菌感染的临床和病因学特征的最新见解，以及免疫机制方面的显著进展。我们希望这将有助于理解这些多样的皮肤真菌感染，并带来可能促进新的诊断和治疗方法的最新进展，以改善这些患者的治疗结果。
