Liang Z T, Liang T T, Jiang Q Z, Yang L
Department of Endodontics, Stomatology Hospital of Guangzhou Medical University & Guangzhou Institute of Oral Disease & Key Laboratory of Oral Medicine, Guangzhou 510140, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2021 Jun 9;56(6):604-607. doi: 10.3760/cma.j.cn112144-20200918-00505.
Dental pulp stem cell (DPSC), with a high capacity of multidirectional differentiation, is the key and preferred cell in the study of dental pulp and dentin regeneration. The effect of trace elements on the differentiation of DPSC is one of the research hotspots in the field of oral tissue engineering in recent years. Trace elements have a wide range of physiological and biochemical functions. It can directly regulate the differentiation, migration and proliferation capacity of DPSC, while can indirectly affect the differentiation of DPSC by exerting antibacterial and immune function regulation or changing the physical and chemical properties of the scaffold material. To clarify the role of trace elements in the differentiation of DPSC can provide more reference for the realization of pulp and dentin regeneration. This paper will review the recent research progress on the effects of relevant trace elements on the differentiation of DPSC into odontogenesis and angiogenesis.
牙髓干细胞（DPSC）具有高多向分化能力，是牙髓和牙本质再生研究中的关键且首选细胞。微量元素对DPSC分化的影响是近年来口腔组织工程领域的研究热点之一。微量元素具有广泛的生理和生化功能。它可以直接调节DPSC的分化、迁移和增殖能力，同时可通过发挥抗菌和免疫功能调节或改变支架材料的物理化学性质来间接影响DPSC的分化。阐明微量元素在DPSC分化中的作用可为实现牙髓和牙本质再生提供更多参考。本文将综述相关微量元素对DPSC向牙生成和血管生成分化影响的最新研究进展。
