Ghosh R, Ghosh P K
Department of Anthropology, University of Delhi, India.
Environ Mol Mutagen. 1988;12(2):179-83. doi: 10.1002/em.2860120204.
The incidence of sister chromatid exchange (SCE) was investigated in the lymphocytes of control women, pregnant women, and women using oral contraceptives after culture at 37 degrees C and 40 degrees C. At 37 degrees C, the mean frequency of SCE (MEAN +/- S.E.) was found to be 7.91 +/- 0.30 in pregnant women and 8.53 +/- 0.29 in oral contraceptive users which were significantly higher than the SCE value of 5.56 +/- 0.21 found in control women. Increase in growth temperature to 40 degrees C elevated the SCE frequency to 11.86 +/- 0.44 in pregnant women, 12.76 +/- 0.46 in oral contraceptive users and 7.24 +/- 0.26 in control women. These data indicate that there is a differential induction of SCEs following increased cell culture temperature in the lymphocytes of pregnant women and oral contraceptive users, compared with control women.
在37摄氏度和40摄氏度培养后，对对照女性、孕妇和使用口服避孕药的女性的淋巴细胞中的姐妹染色单体交换（SCE）发生率进行了研究。在37摄氏度时，孕妇的SCE平均频率（均值±标准误）为7.91±0.30，口服避孕药使用者为8.53±0.29，均显著高于对照女性的SCE值5.56±0.21。将培养温度提高到40摄氏度后，孕妇的SCE频率升高到11.86±0.44，口服避孕药使用者为12.76±0.46，对照女性为7.24±0.26。这些数据表明，与对照女性相比，孕妇和口服避孕药使用者的淋巴细胞在细胞培养温度升高后，SCE的诱导存在差异。
