依托泊苷治疗流行性卡波西肉瘤：一项II期研究。
Etoposide for epidemic Kaposi's sarcoma: a phase II study.
作者信息
Bakker P J, Danner S A, Lange J M, Veenhof K H
机构信息
Division of Medical Oncology, University of Amsterdam, The Netherlands.
出版信息
Eur J Cancer Clin Oncol. 1988 Jun;24(6):1047-8. doi: 10.1016/0277-5379(88)90157-5.
Fourteen untreated patients with epidemic Kaposi's sarcoma stages III and IV were treated with etoposide 150 mg/m2 on 3 consecutive days every 4 weeks. No responses were observed. Myelosuppression was severe with white blood count WHO grade 3-4 in nine patients and with platelets WHO grade 3-4 in one patient. Three patients developed opportunistic infections during therapy. It is concluded that etoposide is inactive in epidemic Kaposi's sarcoma.
14例未经治疗的Ⅲ期和Ⅳ期流行性卡波西肉瘤患者，每4周连续3天接受150mg/m²依托泊苷治疗。未观察到缓解情况。骨髓抑制严重，9例患者白细胞计数达世界卫生组织3 - 4级，1例患者血小板计数达世界卫生组织3 - 4级。3例患者在治疗期间发生机会性感染。结论是依托泊苷对流行性卡波西肉瘤无效。
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