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三环类抗抑郁药与淋巴细胞膜的结合及抑郁期间的变化。

Tricyclic antidepressant binding to lymphocyte membranes and changes during depression.

作者信息

Krulík R, Slíva D, Sikora J, Farská I, Fuksová K

机构信息

Psychiatric Research Unit, Faculty of Medicine, Charles University, Prague, Czechoslovakia.

出版信息

Eur J Pharmacol. 1988 May 10;149(3):357-61. doi: 10.1016/0014-2999(88)90668-1.

DOI:10.1016/0014-2999(88)90668-1
PMID:3409958
Abstract

The binding of [3H]imipramine, its 2- and 4-nitroderivatives and [3H]desmethylimipramine to lymphocyte membranes was determined. IC50 values for drugs and neurotransmitters to inhibit [3H]imipramine binding to lymphocyte membranes were comparable with those for brain and thrombocyte membranes. The number of [3H]imipramine and [3H]desmethylimipramine binding sites increased in depressive patients, whereas the dissociation constants remained unchanged.

摘要

测定了[3H]丙咪嗪、其2-硝基和4-硝基衍生物以及[3H]去甲丙咪嗪与淋巴细胞膜的结合情况。药物和神经递质抑制[3H]丙咪嗪与淋巴细胞膜结合的IC50值与脑和血小板膜的IC50值相当。抑郁症患者中[3H]丙咪嗪和[3H]去甲丙咪嗪结合位点的数量增加，而解离常数保持不变。

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