制动应激对大鼠三环类抗抑郁药结合及5-羟色胺摄取的影响。

Effect of immobilization stress on tricyclic antidepressant binding and serotonin uptake in rats.

作者信息

Farská I, Krulík R, Slíva D

机构信息

Psychiatric Research Unit, Faculty of Medicine, Charles University, Praha, Czechoslovakia.

出版信息

Eur J Pharmacol. 1988 May 10;149(3):363-6. doi: 10.1016/0014-2999(88)90669-3.

DOI:10.1016/0014-2999(88)90669-3

PMID:3409959

Abstract

Immobilization stress increased the density of imipramine binding sites in platelet and cortical membranes and there was an increased serotonin uptake in platelets. There was a decrease in desipramine binding and noradrenaline uptake in lymphocytes. Our results show that stress acts on the mediator systems in various ways.

摘要

制动应激增加了血小板和皮质膜中丙咪嗪结合位点的密度，并且血小板中5-羟色胺摄取增加。淋巴细胞中去甲丙咪嗪结合和去甲肾上腺素摄取减少。我们的结果表明，应激以多种方式作用于介质系统。