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制动应激对大鼠三环类抗抑郁药结合及5-羟色胺摄取的影响。

Effect of immobilization stress on tricyclic antidepressant binding and serotonin uptake in rats.

作者信息

Farská I, Krulík R, Slíva D

机构信息

Psychiatric Research Unit, Faculty of Medicine, Charles University, Praha, Czechoslovakia.

出版信息

Eur J Pharmacol. 1988 May 10;149(3):363-6. doi: 10.1016/0014-2999(88)90669-3.

DOI:10.1016/0014-2999(88)90669-3
PMID:3409959
Abstract

Immobilization stress increased the density of imipramine binding sites in platelet and cortical membranes and there was an increased serotonin uptake in platelets. There was a decrease in desipramine binding and noradrenaline uptake in lymphocytes. Our results show that stress acts on the mediator systems in various ways.

摘要

制动应激增加了血小板和皮质膜中丙咪嗪结合位点的密度,并且血小板中5-羟色胺摄取增加。淋巴细胞中去甲丙咪嗪结合和去甲肾上腺素摄取减少。我们的结果表明,应激以多种方式作用于介质系统。

相似文献

1
Effect of immobilization stress on tricyclic antidepressant binding and serotonin uptake in rats.制动应激对大鼠三环类抗抑郁药结合及5-羟色胺摄取的影响。
Eur J Pharmacol. 1988 May 10;149(3):363-6. doi: 10.1016/0014-2999(88)90669-3.
2
'High affinity' binding of [3H]desipramine to rat cerebral cortex: relationship to tricyclic antidepressant-induced inhibition of norepinephrine uptake.
Eur J Pharmacol. 1981 Apr 9;70(4):597-9. doi: 10.1016/0014-2999(81)90376-9.
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Specific tricyclic antidepressant binding sites in rat brain.
Nature. 1979 Sep 13;281(5727):148-50. doi: 10.1038/281148a0.
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Antidepressant binding sites in brain.
Clin Sci (Lond). 1984 Oct;67(4):369-73. doi: 10.1042/cs0670369.
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Antidepressant binding: implications for the mode of action and the biology of depression.抗抑郁药结合:对抑郁症作用模式及生物学机制的影响
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):457-62. doi: 10.1016/0278-5846(83)90011-8.
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3H-imipramine and 3H-desipramine binding sites in depression.抑郁症中3H-丙咪嗪和3H-地昔帕明结合位点
Adv Biochem Psychopharmacol. 1984;39:113-25.
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Binding of [3H]imipramine and [3H]desipramine as biochemical tools for studies in depression.
Neuropharmacology. 1983 Mar;22(3 Spec No):407-13. doi: 10.1016/0028-3908(83)90190-9.
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[3H]Desipramine and [3H]imipramine binding are not associated with noradrenaline and serotonin uptake in the brain.
Eur J Pharmacol. 1982 Mar 26;78(4):491-3. doi: 10.1016/0014-2999(82)90496-4.
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Effect of some tricyclic and nontricyclic antidepressants on [3H]imipramine binding and serotonin uptake in rat cerebral cortex after prolonged treatment.
Fundam Clin Pharmacol. 1987;1(5):327-33. doi: 10.1111/j.1472-8206.1987.tb00570.x.
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Hydroxylated metabolites of tricyclic antidepressants: preclinical assessment of activity.三环类抗抑郁药的羟基化代谢产物:活性的临床前评估
Biol Psychiatry. 1979 Aug;14(4):601-13.

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