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TC10 as an essential molecule in axon regeneration through membrane supply and microtubule stabilization.

作者信息

Nakamura Takeshi, Koinuma Shingo

机构信息

Division of Cell Signaling, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan.

出版信息

Neural Regen Res. 2022 Jan;17(1):87-88. doi: 10.4103/1673-5374.314297.

DOI:10.4103/1673-5374.314297
PMID:34100433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8451582/
Abstract
摘要

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1
TC10 as an essential molecule in axon regeneration through membrane supply and microtubule stabilization.作为轴突再生中通过膜供应和微管稳定起关键作用的分子,TC10。
Neural Regen Res. 2022 Jan;17(1):87-88. doi: 10.4103/1673-5374.314297.
2
TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner.TC10,一种 Rho 家族 GTPase,以神经元自主的方式对有效轴突再生是必需的。
J Neurochem. 2021 May;157(4):1196-1206. doi: 10.1111/jnc.15235. Epub 2020 Nov 27.
3
The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons.TC10-Exo70复合物对于发育中神经元的膜扩张和轴突特化至关重要。
J Neurosci. 2009 Oct 21;29(42):13292-301. doi: 10.1523/JNEUROSCI.3907-09.2009.
4
GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.TC10的GTP水解通过释放外排体成分Exo70,促进含Rab11和L1的囊泡的胞吐融合,从而促进神经突生长。
PLoS One. 2013 Nov 4;8(11):e79689. doi: 10.1371/journal.pone.0079689. eCollection 2013.
5
Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism.抑制驱动蛋白-5 通过一种新的基于微管的机制改善损伤轴突的再生。
Neural Regen Res. 2015 Jun;10(6):845-9. doi: 10.4103/1673-5374.158351.
6
Local translation of TC10 is required for membrane expansion during axon outgrowth.轴突生长过程中膜扩张需要TC10的局部翻译。
Nat Commun. 2014 Mar 25;5:3506. doi: 10.1038/ncomms4506.
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cAMP-induced activation of protein kinase A and p190B RhoGAP mediates down-regulation of TC10 activity at the plasma membrane and neurite outgrowth.环磷酸腺苷(cAMP)诱导的蛋白激酶A和p190B RhoGAP激活介导了质膜上TC10活性的下调以及神经突生长。
Genes Cells. 2017 Nov;22(11):953-967. doi: 10.1111/gtc.12538. Epub 2017 Oct 26.
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The small GTP-binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats.小GTP结合蛋白TC10促进神经元细胞中的神经伸长,并且其表达在大鼠神经再生过程中被诱导。
J Neurosci. 2000 Jun 1;20(11):4138-44. doi: 10.1523/JNEUROSCI.20-11-04138.2000.
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Loureirin B Promotes Axon Regeneration by Inhibiting Endoplasmic Reticulum Stress: Induced Mitochondrial Dysfunction and Regulating the Akt/GSK-3β Pathway after Spinal Cord Injury.小豆蔻明 B 通过抑制内质网应激促进轴突再生:脊髓损伤后诱导的线粒体功能障碍和调节 Akt/GSK-3β 通路。
J Neurotrauma. 2019 Jun 15;36(12):1949-1964. doi: 10.1089/neu.2018.5966. Epub 2019 Feb 25.
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Axon injury and stress trigger a microtubule-based neuroprotective pathway.轴突损伤和应激会触发基于微管的神经保护途径。
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引用本文的文献

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βPix Guanine Nucleotide Exchange Factor Regulates Regeneration of Injured Peripheral Axons.βPix 鸟嘌呤核苷酸交换因子调节损伤外周轴突的再生。
Int J Mol Sci. 2023 Sep 20;24(18):14357. doi: 10.3390/ijms241814357.

本文引用的文献

1
TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner.TC10,一种 Rho 家族 GTPase,以神经元自主的方式对有效轴突再生是必需的。
J Neurochem. 2021 May;157(4):1196-1206. doi: 10.1111/jnc.15235. Epub 2020 Nov 27.
2
Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.Protrudin 从内质网发挥作用,以支持成年中枢神经系统中的轴突再生。
Nat Commun. 2020 Nov 5;11(1):5614. doi: 10.1038/s41467-020-19436-y.
3
βPix-d promotes tubulin acetylation and neurite outgrowth through a PAK/Stathmin1 signaling pathway.
βPix-d 通过 PAK/Stathmin1 信号通路促进微管乙酰化和神经突生长。
PLoS One. 2020 Apr 6;15(4):e0230814. doi: 10.1371/journal.pone.0230814. eCollection 2020.
4
The guanine nucleotide exchange factor Arhgef7/βPix promotes axon formation upstream of TC10.鸟嘌呤核苷酸交换因子 Arhgef7/βPix 促进 TC10 上游的轴突形成。
Sci Rep. 2018 Jun 11;8(1):8811. doi: 10.1038/s41598-018-27081-1.
5
Can injured adult CNS axons regenerate by recapitulating development?成年中枢神经系统受损轴突能否通过重现发育过程来实现再生?
Development. 2017 Oct 1;144(19):3417-3429. doi: 10.1242/dev.148312.
6
Selective rab11 transport and the intrinsic regenerative ability of CNS axons.选择性 rab11 转运和中枢神经系统轴突的固有再生能力。
Elife. 2017 Aug 8;6:e26956. doi: 10.7554/eLife.26956.
7
Gene Manipulation Strategies to Identify Molecular Regulators of Axon Regeneration in the Central Nervous System.用于鉴定中枢神经系统轴突再生分子调节因子的基因操作策略
Front Cell Neurosci. 2017 Aug 7;11:231. doi: 10.3389/fncel.2017.00231. eCollection 2017.
8
Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis.驱动蛋白-6 Kif20b的突变导致皮质神经元极化和形态发生缺陷。
Neural Dev. 2017 Mar 31;12(1):5. doi: 10.1186/s13064-017-0082-5.
9
Neural activity promotes long-distance, target-specific regeneration of adult retinal axons.神经活动促进成年视网膜轴突的长距离、靶向特异性再生。
Nat Neurosci. 2016 Aug;19(8):1073-84. doi: 10.1038/nn.4340. Epub 2016 Jul 11.
10
Mitochondrial fission is an acute and adaptive response in injured motor neurons.线粒体分裂是受损运动神经元的一种急性适应性反应。
Sci Rep. 2016 Jun 20;6:28331. doi: 10.1038/srep28331.