恢复期新冠患者中出现和未出现 RT-PCR 复阳结果的抗体反应。
Antibody response in COVID-19 patients with and without re-positive RT-PCR results during the convalescent phase.
机构信息
Shenzhen Sami Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiang'an South Road, Xiamen, 361102, Fujian, China.
出版信息
Arch Virol. 2021 Aug;166(8):2299-2303. doi: 10.1007/s00705-021-05132-9. Epub 2021 Jun 8.
Nucleic acid testing and antibody testing data from 143 recovered COVID-19 patients during the convalescent phase were retrospectively analyzed. A total of 23 (16.1%) recovered patients re-tested positive for SARS-CoV-2 RNA by RT-PCR. Three months after symptom onset, 100% and 99.3% of the patients remained positive for total and IgG antibodies, and the antibody levels remained high. IgM antibodies declined rapidly, with a median time to seroconversion of 67 (95% CI: 59, 75) days after onset. Approximately 25% of patients were seronegative for IgA antibodies at three months after onset. There was no statistically significant difference in antibody kinetics between patients with and without re-positive RT-PCR results during the convalescent phase.
对 143 例恢复期 COVID-19 患者的核酸检测和抗体检测数据进行了回顾性分析。共有 23 例（16.1%）康复患者的 SARS-CoV-2 RNA 经 RT-PCR 再次检测呈阳性。症状出现后 3 个月，100%和 99.3%的患者总抗体和 IgG 抗体仍呈阳性，抗体水平仍保持较高水平。IgM 抗体迅速下降，发病后 67 天（95%CI：59，75）中位数达到血清转换。大约 25%的患者在发病后 3 个月时 IgA 抗体呈阴性。恢复期 RT-PCR 结果再次阳性的患者与无再次阳性 RT-PCR 结果的患者的抗体动力学无统计学差异。
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