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通过分解随机反应网络获得稳定分布。

Stationary distributions via decomposition of stochastic reaction networks.

机构信息

Department of Mathematical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

J Math Biol. 2021 Jun 8;82(7):67. doi: 10.1007/s00285-021-01620-3.

Abstract

We examine reaction networks (CRNs) through their associated continuous-time Markov processes. Studying the dynamics of such networks is in general hard, both analytically and by simulation. In particular, stationary distributions of stochastic reaction networks are only known in some cases. We analyze class properties of the underlying continuous-time Markov chain of CRNs under the operation of join and examine conditions such that the form of the stationary distributions of a CRN is derived from the parts of the decomposed CRNs. The conditions can be easily checked in examples and allow recursive application. The theory developed enables sequential decomposition of the Markov processes and calculations of stationary distributions. Since the class of processes expressible through such networks is big and only few assumptions are made, the principle also applies to other stochastic models. We give examples of interest from CRN theory to highlight the decomposition.

摘要

我们通过相关的连续时间马尔可夫过程来研究反应网络 (CRN)。研究这些网络的动力学通常是困难的,无论是在分析上还是通过模拟。特别是,随机反应网络的平稳分布仅在某些情况下已知。我们分析了在连接操作下 CRN 所对应的连续时间马尔可夫链的类属性,并研究了一些条件,使得 CRN 的平稳分布的形式可以从分解的 CRN 的部分中推导出。这些条件可以在示例中轻松检查,并允许递归应用。所开发的理论允许对马尔可夫过程进行顺序分解和计算平稳分布。由于可以通过此类网络表达的过程类很大,并且仅做出了很少的假设,因此该原理也适用于其他随机模型。我们给出了来自 CRN 理论的感兴趣的示例,以突出分解。

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本文引用的文献

1
Joining and decomposing reaction networks.反应网络的连接与分解。
J Math Biol. 2020 May;80(6):1683-1731. doi: 10.1007/s00285-020-01477-y. Epub 2020 Mar 2.
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Dynamical properties of Discrete Reaction Networks.离散反应网络的动力学性质
J Math Biol. 2014 Jul;69(1):55-72. doi: 10.1007/s00285-013-0686-2. Epub 2013 May 31.
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Intrinsic noise in gene regulatory networks.基因调控网络中的内在噪声。
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8614-9. doi: 10.1073/pnas.151588598. Epub 2001 Jul 3.

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