Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Graduate University of Advanced Technology, Kerman, 7631818356, Iran.
Department of Nanotechnology, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran.
Mikrochim Acta. 2021 Jun 8;188(7):224. doi: 10.1007/s00604-021-04876-0.
Diagnosis, treatment, and prediction of cancer progression require new targeting agents to specifically target cell surface receptors. Herein, we demonstrated fluorescent carbon quantum dots-molecularly imprinted polymer (CQD-MIP) for selective targeting and imaging of cancer cells. Carbon quantum dots (CQDs) were synthesized and characterized. The synthesized CQDs had average size of 1.5 nm and show intense fluorescence emission at wavelength of 450 nm with excitation at 370 nm. CQD-MIP nanoparticles imprinted with N-acetylneuraminic acid and glucuronic acid were prepared and characterized. CQD-MIPs were successfully applied for selective targeting and imaging of MCF-7, HepG-2, and NIH-3T3 cell lines. Non-imprinted polymer (NIP) showed no binding properties toward a target molecule. Non-imprinted polymer (NIP) and non-cancerous human cell lines were used for controlling the imprinting and targeting effects, respectively. Acceptable results were obtained with imprinted polymers on cancer cells.
癌症进展的诊断、治疗和预测需要新的靶向药物来特异性靶向细胞表面受体。在此，我们展示了用于选择性靶向和成像癌细胞的荧光碳量子点-分子印迹聚合物（CQD-MIP）。合成并表征了碳量子点（CQD）。合成的 CQD 的平均尺寸为 1.5nm，并在波长为 450nm 处显示出强烈的荧光发射，激发波长为 370nm。用 N-乙酰神经氨酸和葡萄糖醛酸制备并表征了印迹有 CQD-MIP 的纳米颗粒。CQD-MIP 成功应用于 MCF-7、HepG-2 和 NIH-3T3 细胞系的选择性靶向和成像。非印迹聚合物（NIP）对靶分子没有结合特性。非印迹聚合物（NIP）和非癌细胞系分别用于控制印迹和靶向作用。在癌细胞上的印迹聚合物上获得了可接受的结果。
