Gei P, Cuccia C, Bonaldi E, Pagnoni N, Volpini M, Berra P, Ettori F, Niccoli L, Riva S
Cattedra e Divisione di Cardiologia, Università degli Studi e Spedali Civili di Brescia.
G Ital Cardiol. 1988 Feb;18(2):90-6.
The purpose of our study was to evaluate, during the early phase, the coronary anatomy of the patients who suffered from an acute non-Q myocardial infarction (non-Q MI) and to correlate it with the ECG findings and with clinical evolution. We studied 76 patients (pts.), mean age 56 +/- 9 years, who had their a first non-Q MI (reinfarctions non included). They all underwent angiographic examination within an average period of 18 days (range 5-30 days). In the whole group of patients it is worthwhile noting: A) the elevated occurrence of left main lesions (11% of pts.) and multivessel disease (60%); B) the great percentage (41%) of patients with open infarct-related vessel but with very critical residual stenosis (above 90% of total lumen); C) the presence of collateral vessels in almost all the pts. (91%) with totally occluded infarct-related artery. During the 12 month follow-up, in all groups was a high occurrence (above 70%) of coronary events (postinfarction angina, reinfarction, aortocoronary by pass or PTCA). Furthermore, it is possible to identify a subgroup of patients presenting ST-segment depression with very unfavourable coronary anatomy (80% had multivessel disease, 30% of which had a left main critical stenosis) and high prognostic risk (90% occurrence of coronary events). In the subgroup with ST-segment elevation there was an elevated percentage (65%) of open infarct-related vessel, but with an important residual stenosis. Considering the advantages of revascularization interventions in these high risk patients with extensive residual jeopardized myocardium, we conclude that it is important that all patients with non-Q MI undergo early coronary angiography.
我们研究的目的是在早期评估急性非Q波心肌梗死(非Q波MI)患者的冠状动脉解剖结构,并将其与心电图表现及临床病程相关联。我们研究了76例患者,平均年龄56±9岁,均为首次发生非Q波MI(不包括再梗死)。他们均在平均18天(5 - 30天)内接受了血管造影检查。在整个患者组中,值得注意的是:A)左主干病变(占患者的11%)和多支血管病变(60%)的发生率较高;B)梗死相关血管开通但残余狭窄非常严重(超过管腔总面积的90%)的患者比例很大(41%);C)几乎所有梗死相关动脉完全闭塞的患者(91%)都存在侧支血管。在12个月的随访期间,所有组中冠状动脉事件(梗死后心绞痛、再梗死、主动脉冠状动脉搭桥术或经皮冠状动脉腔内血管成形术)的发生率都很高(超过70%)。此外,有可能识别出一个亚组患者,他们表现为ST段压低,冠状动脉解剖结构非常不利(80%有多支血管病变,其中30%有左主干严重狭窄)且预后风险高(冠状动脉事件发生率为90%)。在ST段抬高的亚组中,梗死相关血管开通的比例较高(65%),但存在重要的残余狭窄。考虑到在这些有广泛残余濒危心肌的高危患者中进行血运重建干预的优势,我们得出结论,所有非Q波MI患者早期进行冠状动脉造影很重要。