Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan.
J Coll Physicians Surg Pak. 2021 Jun;31(6):728-731. doi: 10.29271/jcpsp.2021.06.728.
Sulphamate drugs, widely prescribed for various systemic conditions, are reported to have rare ocular adverse-effects, usually within weeks of initiation of treatment. Medical and drug history in such cases are of pivotal importance in reaching a proper diagnosis. This study reports three cases, which developed topiramate-induced ocular side effects. In one of the cases, although the angles were narrow in both eyes, yet intra-ocular pressure (IOP) was not high. Also, in the third case, there were no macular striae. Topiramate was immediately withheld and all cases were improved without any permanent ocular damage. Key Words: Sulphamate, Topiramate, Angle closure glaucoma, Myopia.
磺胺类药物被广泛用于治疗各种系统性疾病，但据报道，它们也会引起罕见的眼部不良反应，通常在治疗开始后的数周内出现。在这种情况下，药物和病史对于做出正确的诊断至关重要。本研究报告了三例托吡酯引起的眼部副作用病例。其中一例虽然双眼的房角狭窄，但眼压不高。第三例也没有黄斑条纹。立即停止使用托吡酯后，所有病例均有所改善，没有造成永久性眼部损害。关键词：磺胺类，托吡酯，闭角型青光眼，近视。
