Department of Clinical Pharmacy, Tanta University, Tanta, Egypt.
Diabetes and Endocrinology Unit, Department of Internal Medicine, Tanta University, Tanta, Egypt.
Clin Ther. 2021 Jul;43(7):e230-e240. doi: 10.1016/j.clinthera.2021.05.003. Epub 2021 Jun 5.
This study aimed to evaluate the role of the extracellular part of insulin-regulated aminopeptidase (IRAPe), interleukin (IL)-34, irisin, and visfatin in the development of insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).
This observational parallel-group study was conducted in 60 subjects without T2DM who served as a control group and 60 patients with newly diagnosed T2DM. The 2 groups were matched for age, sex ratio, and body mass index. Anthropometric parameters; fasting blood glucose; fasting plasma insulin; Homeostatic Model Assessment for IR (HOMA-IR) index; glycated hemoglobin (HbA); and circulating levels of IL-34, visfatin, irisin, and IRAPe were assessed.
The group with T2DM showed significantly higher IL-34 and visfatin levels and significantly lower irisin and IRAPe levels as compared to the healthy control group. IL-34 and visfatin were significantly positively correlated with fasting blood glucose, fasting plasma insulin, HOMA-IR, and HbA. On the other hand, irisin and IRAPe were significantly negatively correlated with fasting blood glucose, fasting plasma insulin, HOMA-IR, and HbA. IL-34 was positively associated with visfatin, while negatively associated with both irisin and IRAPe.
IL-34, visfatin, irisin, and IRAPe may play a vital role in T2DM and in diabetes-associated IR. Additionally, IRAPe may represent a useful and direct marker for use in the detection of IR in the diabetic population. ClinicalTrials.gov identifier: NCT04107259.
本研究旨在评估胰岛素调节氨肽酶（IRAPe）的细胞外部分、白细胞介素（IL）-34、鸢尾素和内脂素在 2 型糖尿病（T2DM）患者胰岛素抵抗（IR）发展中的作用。
本观察性平行组研究纳入 60 例无 T2DM 的患者作为对照组和 60 例新诊断的 T2DM 患者。两组在年龄、性别比和体重指数方面相匹配。评估了人体测量参数、空腹血糖、空腹血浆胰岛素、胰岛素抵抗评估的稳态模型（HOMA-IR）指数、糖化血红蛋白（HbA）以及循环中的 IL-34、内脂素、鸢尾素和 IRAPe 水平。
与健康对照组相比，T2DM 组的 IL-34 和内脂素水平明显更高，而鸢尾素和 IRAPe 水平明显更低。IL-34 和内脂素与空腹血糖、空腹血浆胰岛素、HOMA-IR 和 HbA 呈显著正相关。另一方面，鸢尾素和 IRAPe 与空腹血糖、空腹血浆胰岛素、HOMA-IR 和 HbA 呈显著负相关。IL-34 与内脂素呈正相关，与鸢尾素和 IRAPe 呈负相关。
IL-34、内脂素、鸢尾素和 IRAPe 在 T2DM 和糖尿病相关的 IR 中可能发挥重要作用。此外，IRAPe 可能代表一种有用的直接标志物，用于检测糖尿病人群中的 IR。临床试验编号：NCT04107259。
