Cone E J, Menchen S L, Mitchell J
National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.
Forensic Sci Int. 1988 Jun;37(4):265-75. doi: 10.1016/0379-0738(88)90235-6.
Clinical specimens obtained from human subjects after intravenous cocaine administration were analyzed by the TDx Cocaine Metabolite Assay (TDx) and by GC/MS for benzoylecgonine. The TDx results were significantly correlated with results by GC/MS assay with no evidence of bias in the TDx assay. All cocaine metabolite positive specimens (greater than or equal to 300 ng/ml) were confirmed by GC/MS. Detection times to the last positive specimen by TDx assay and GC/MS assay of four subjects after a 20-mg intravenous dose of cocaine ranged from 29.3 to 39.1 h and 27.9 and 36.6 h, respectively. Overall, the TDx assay was found to be highly specific and accurate for the detection and measurement of benzoylecgonine in urine.
通过TDx可卡因代谢物检测法（TDx）以及气相色谱/质谱联用仪（GC/MS）对静脉注射可卡因后的人体受试者采集的临床样本进行苯甲酰芽子碱分析。TDx检测结果与GC/MS检测结果显著相关，且未发现TDx检测存在偏差。所有可卡因代谢物阳性样本（大于或等于300 ng/ml）均通过GC/MS得到确认。四名受试者静脉注射20毫克可卡因后，TDx检测法和GC/MS检测法检测到最后一份阳性样本的时间分别为29.3至39.1小时和27.9至36.6小时。总体而言，发现TDx检测法在尿液中苯甲酰芽子碱的检测和测量方面具有高度特异性和准确性。
