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先天性主动脉瓣狭窄的球囊和外科瓣膜成形术结果:一项为期19年的单中心回顾性研究。

Results of balloon and surgical valvuloplasty in congenital aortic valve stenosis: A 19-year, single-center, retrospective study.

作者信息

Yakut Kahraman, Tokel Niyazi Kürşad, Varan Birgül, Erdoğan İlkay, Özkan Murat

机构信息

Department of Child Health and Diseases, Division of Pediatric Cardiology, Başkent University Faculty of Medicine, Ankara, Turkey.

Department of Cardiovascular Surgery, Başkent University Faculty of Medicine, Ankara, Turkey.

出版信息

Turk Gogus Kalp Damar Cerrahisi Derg. 2021 Apr 26;29(2):158-165. doi: 10.5606/tgkdc.dergisi.2021.20564. eCollection 2021 Apr.

Abstract

BACKGROUND

This study aims to compare the success, complications, and long-term outcomes of aortic balloon valvuloplasty and surgical aortic valvuloplasty in pediatric patients with congenital aortic valve stenosis.

METHODS

Between March 2000 and October 2019, a total of 267 procedures, including 238 balloon valvuloplasties and 29 surgical valvuloplasties, in 198 children (135 males, 63 females; mean age: 57.4±62.6 months; range, 0.03 to 219 months) were retrospectively analyzed. The hospital records, echocardiographic images, catheterization data, angiography images, and operative data were reviewed.

RESULTS

Aortic regurgitation was mild in 73 patients before balloon valvuloplasty, and none of the patients had moderate-to-severe aortic regurgitation. Compared to surgical valvuloplasty, the rate of increase in the aortic regurgitation after balloon valvuloplasty was significantly higher (p=0.012). The patients who underwent balloon valvuloplasty did not need reintervention for a mean period of 46±45.6 months, whereas this period was significantly longer in those who underwent surgical valvuloplasty (mean 80.5±53.9 months) (p=0.018). The overall failure rate was 8%. Moderate-to-severe aortic regurgitation was the most important complication developing due to balloon valvuloplasty in the early period (13%). All surgical valvuloplasties were successful. The mean length of hospitalization after balloon valvuloplasty was significantly shorter than surgical valvuloplasty (p=0.026). During follow-up, a total of 168 patients continued their follow-up, and a reinterventional or surgical intervention was not needed in 78 patients (47%).

CONCLUSION

Aortic balloon valvuloplasty can be repeated safely and helps to eliminate aortic valve stenosis without needing sternotomy. Surgical valvuloplasty can be successfully performed in patients in whom the expected benefit from aortic balloon valvuloplasty is not achieved.

摘要

背景

本研究旨在比较先天性主动脉瓣狭窄患儿行主动脉球囊瓣膜成形术和外科主动脉瓣膜成形术的成功率、并发症及长期预后。

方法

回顾性分析2000年3月至2019年10月期间198例儿童(135例男性,63例女性;平均年龄:57.4±62.6个月;范围,0.03至219个月)接受的267例手术,包括238例球囊瓣膜成形术和29例外科瓣膜成形术。查阅医院记录、超声心动图图像、导管检查数据、血管造影图像及手术数据。

结果

球囊瓣膜成形术前73例患者存在轻度主动脉瓣反流,无中度至重度主动脉瓣反流患者。与外科瓣膜成形术相比,球囊瓣膜成形术后主动脉瓣反流增加率显著更高(p=0.012)。接受球囊瓣膜成形术的患者平均46±45.6个月无需再次干预,而接受外科瓣膜成形术的患者此期间显著更长(平均80.5±53.9个月)(p=0.018)。总体失败率为8%。早期因球囊瓣膜成形术导致的最重要并发症为中度至重度主动脉瓣反流(13%)。所有外科瓣膜成形术均成功。球囊瓣膜成形术后平均住院时间显著短于外科瓣膜成形术(p=0.026)。随访期间,共168例患者继续接受随访,78例患者(47%)无需再次干预或手术干预。

结论

主动脉球囊瓣膜成形术可安全重复进行,有助于消除主动脉瓣狭窄且无需开胸。对于未从主动脉球囊瓣膜成形术获得预期益处的患者,可成功实施外科瓣膜成形术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a73a/8167465/eb2816fbf7b3/TJTCS-2021-29-2-158-165-F1.jpg

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