Mize Brandi M, Duke Brandon, Pangle Amanda K, Wei Jeanne Y, Azhar Gohar
UAMS, Little Rock, AR, USA.
Gerontol Geriatr Med. 2021 May 26;7:23337214211018933. doi: 10.1177/23337214211018933. eCollection 2021 Jan-Dec.
Cardiovascular disease is a common comorbidity associated with an aging population. However, there is a unique group of individuals whose age-defying qualities are still being investigated. This retrospective chart review analyzed various cardiac and metabolic health parameters to characterize the prevalence of heart failure and metabolic derangements in individuals aged 90 years old or older in central Arkansas. Only 236 of the 291 patients in our study cohort had blood pressures recorded. Of these, 50% had systolic blood pressures ≥140 mmHg. Additionally, 77% had pulse pressures ≥50 mmHg. Of the 96 patients with BNP data, 44% had values ≥300 pg/mL. There was a slight positive correlation between aging and HDL cholesterol, while there was a negative correlation between aging and both total cholesterol and LDL cholesterol. A majority of our patients had both elevated systolic blood pressures and elevated pulse pressures. A majority also had high BNP values, indicative of some degree of heart failure. Additionally, atrial fibrillation was a common arrhythmia identified on EKG. However, these oldest of the old patients had fewer documented metabolic derangements. These findings lay important groundwork for further investigation into lifestyle and genetic components that allow them to live exceptionally long with such comorbidities.
心血管疾病是与人口老龄化相关的常见合并症。然而，有一群独特的个体，其抗衰老特质仍在研究中。这项回顾性病历审查分析了各种心脏和代谢健康参数，以描述阿肯色州中部90岁及以上个体中心力衰竭和代谢紊乱的患病率。在我们的研究队列中的291名患者中，只有236名患者记录了血压。其中，50%的患者收缩压≥140 mmHg。此外，77%的患者脉压≥50 mmHg。在96名有BNP数据的患者中，44%的值≥300 pg/mL。衰老与高密度脂蛋白胆固醇之间存在轻微正相关，而衰老与总胆固醇和低密度脂蛋白胆固醇之间均呈负相关。我们的大多数患者收缩压和脉压均升高。大多数患者的BNP值也很高，表明存在一定程度的心力衰竭。此外，心房颤动是心电图上常见的心律失常。然而，这些最年长的患者记录的代谢紊乱较少。这些发现为进一步研究使他们在患有此类合并症的情况下仍能长寿的生活方式和遗传因素奠定了重要基础。
